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Abstract This chapter presents the case of a 61-year-old man with painful, asymmetric, sensory-predominant polyneuropathy; clinicians ultimately diagnose AL amyloid neuropathy through nerve biopsy. It traces the historical and molecular understanding of amyloidosis, emphasizing its heterogeneity and classifying major subtypes—AA, AL ...
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Amyloid Neuropathy and Multiple Myeloma
European Neurology, 2008Report of 2 patients suffering from sensory peripheral neuropathy and multiple myeloma. In 1 case, peripheral neuropathy occurred several months before the appearance of multiple myeloma. A peripheral nerve biopsy exhibited numerous amyloid deposits within the endoneurium.
C. Vital +7 more
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Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1991
Formation of amyloid within peripheral nerves, resulting in amyloid-related neuropathies, may occur when myeloma-associated amyloid (AL) is deposited in an immune-related neuropathy or in familial amyloid polyneuropathy where prealbumin/transthyretin variants are marked by AF amyloid deposition.
H H, Goebel, J, Bohl, S, Störkel
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Formation of amyloid within peripheral nerves, resulting in amyloid-related neuropathies, may occur when myeloma-associated amyloid (AL) is deposited in an immune-related neuropathy or in familial amyloid polyneuropathy where prealbumin/transthyretin variants are marked by AF amyloid deposition.
H H, Goebel, J, Bohl, S, Störkel
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Journal of the neurological sciences, 1983
The development of amyloid neuropathy is an uncommon complication of multiple myeloma. The clinical, electrophysiological and pathological features of 3 such patients are described. The small fiber neuropathy in these 3 cases was similar to that in patients with primary amyloidosis and with the Andrade-type of familial neuropathy, and differed from the
J. P. Verghese +3 more
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The development of amyloid neuropathy is an uncommon complication of multiple myeloma. The clinical, electrophysiological and pathological features of 3 such patients are described. The small fiber neuropathy in these 3 cases was similar to that in patients with primary amyloidosis and with the Andrade-type of familial neuropathy, and differed from the
J. P. Verghese +3 more
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Rinsho shinkeigaku = Clinical neurology, 1991
Primary amyloidosis and myeloma associated amyloidosis causes neuropathy in 10% of the cases, and hemodialysis associated amyloidosis causes carpal tunnel syndrome. However, most severe amyloid neuropathy is observed in familial amyloidotic polyneuropathy (FAP).
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Primary amyloidosis and myeloma associated amyloidosis causes neuropathy in 10% of the cases, and hemodialysis associated amyloidosis causes carpal tunnel syndrome. However, most severe amyloid neuropathy is observed in familial amyloidotic polyneuropathy (FAP).
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[Familial amyloid neuropathies].
Revue neurologique, 1994Recent advances in molecular biology have given improved knowledge of familial amyloidotic polyneuropathies (FAP). FAP, originally described in Portuguese patients have been observed in many countries. These neuropathies are characterized by a sensory motor deficit beginning in the lower limbs and associated with autonomic nervous system involvement ...
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Hereditary neuropathies: A pathological perspective
Journal of the Peripheral Nervous System, 2021Gian Maria Fabrizi +2 more
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