Results 51 to 60 of about 36,206 (272)

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core   +1 more source

Apolipoprotein E modulates γ‐secretase cleavage of the amyloid precursor protein [PDF]

Journal of Neurochemistry, 2004
AbstractPolymorphisms in the apolipoprotein E (APOE) gene affect the risk of Alzheimer disease and the amount of amyloid β‐protein (Aβ) deposited in the brain. The apoE protein reduces Aβ levels in conditioned media from cells in culture, possibly through Aβ clearance mechanisms.
Michael C, Irizarry, Amy, Deng, Alberto, Lleo, Oksana, Berezovska, Christine A F, Von Arnim, Matthew, Martin-Rehrmann, Arlene, Manelli, Mary Jo, LaDu, Bradley T, Hyman, G William, Rebeck   +9 more
openaire   +2 more sources

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

Medical Sciences, 2018
The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving ...
Vladimir Volloch, Sophia Rits
doaj   +1 more source

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

Neurobiology of Disease, 2003
γ-Secretase is a proteolytic complex whose substrates include Notch, β-amyloid precursor protein (APP), and several other type I transmembrane proteins. Presenilin (PS) and nicastrin are known components of this high-molecular-weight complex, and recent ...
Stephanie Baulac, Matthew J LaVoie, W.Taylor Kimberly, Jennifer Strahle, Michael S Wolfe, Dennis J Selkoe, Weiming Xia   +6 more
doaj   +1 more source

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]

, 2008
Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Czirr, Eva, Esselmann, Hermann, Leuchtenberger, Stefanie, Lichtenthaler, Stefan F., Maler, Juan, Ness, Julia, Pietrzik, Claus U., Weggen, Sascha, Wiltfang, Jens   +8 more
core   +1 more source

P2Y2 Nucleotide Receptors Enhance α-Secretase-dependent Amyloid Precursor Protein Processing [PDF]

Journal of Biological Chemistry, 2005
The amyloid precursor protein (APP) is proteolytically processed by beta- and gamma-secretases to release amyloid beta, the main component in senile plaques found in the brains of patients with Alzheimer disease. Alternatively, APP can be cleaved within the amyloid beta domain by alpha-secretase releasing the non-amyloidogenic product sAPP alpha, which
Jean M, Camden, Ann M, Schrader, Ryan E, Camden, Fernando A, González, Laurie, Erb, Cheikh I, Seye, Gary A, Weisman   +6 more
openaire   +2 more sources

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]

, 2016
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio, Daugherty, Daniel, M Armando, Aaron, Maher, Pam, Quehenberger, Oswald, Schubert, David   +5 more
core   +2 more sources

Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease

Neural Regeneration Research
γ-Secretase, called “the proteasome of the membrane,” is a membrane-embedded protease complex that cleaves 150+ peptide substrates with central roles in biology and medicine, including amyloid precursor protein and the Notch family of cell-surface ...
Yinglong Miao, Michael S. Wolfe
doaj   +1 more source

Visualization of Alzheimer’s Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer

Frontiers in Molecular Neuroscience, 2018
The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation.
Xin Wang, Gang Pei, Gang Pei
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Knock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes [PDF]

, 2014
Footnotes We thank Roemex and the College for Life Science and Medicine at the University of Aberdeen for their generous support.
Crouch, Barry, Koss, David, Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne   +5 more
core   +1 more source