When the Body Falls Silent: A Case Report of Amyotrophic Lateral Sclerosis. [PDF]
CureusPereira de Oliveira M, Lima Monteiro F.
europepmc +1 more source
Quality of life over time after new onset refractory status epilepticus
Epilepsia, EarlyView.Abstract Objective This study aims to better characterize the long‐term neurological quality of life (QOL) outcomes (using the Neuro‐QOL scale) in survivors of new onset refractory status epilepticus (NORSE), including its subtype febrile infection‐related epilepsy syndrome (FIRES), and provide guidance for psychological and social support strategies ...
Matthew D. Gruen +29 more
wiley +1 more source
Illness acceptance and quality of life in amyotrophic lateral sclerosis: the role of health and environmental factors. [PDF]
Front NeurolCzyżewski Ł +8 more
europepmc +1 more source
Clinical and epidemiological characteristics of amyotrophic lateral sclerosis in an Egyptian cohort [PDF]
Radwa Soliman +3 more
openalex +1 more source
Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, EarlyView.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Clinical and genetic determinants of survival in amyotrophic lateral sclerosis patients from North India. [PDF]
Brain CommunKhurana S +9 more
europepmc +1 more source
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau
The FEBS Journal, EarlyView.E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki +8 more
wiley +1 more source
Urinary P75: a promising biomarker for amyotrophic lateral sclerosis. [PDF]
BMJ Neurol OpenChapman LR +6 more
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Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, EarlyView.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source