Results 341 to 350 of about 242,580 (385)

Hereditary amyotrophic lateral sclerosis

Journal of the Neurological Sciences, 1981
A Spanish family transmits, as an autosomal dominant trait, a form of amyotrophic lateral sclerosis characterized by an unusually prolonged evolution of the disease in all affected members. Precocity and persistence of muscle cramps, presence of unilateral proximal segmental myoclonus and early abolition of ankle jerks are other clinical features ...
R, Alberca, J M, Castilla, A, Gil-Peralta   +2 more
openaire   +2 more sources

Hereditary amyotrophic lateral sclerosis

Journal of the Neurological Sciences, 1969
Abstract We report the clinical and histopathological findings in a patient affected by a hereditary form of amyotrophic lateral sclerosis (ALS). The paper includes a clinical description of 11 other members of the same family and comments upon genetic considerations in this family.
A F, Thomson, F A, Alvarez
openaire   +2 more sources

Serum neurofilament light chain at time of diagnosis is an independent prognostic factor of survival in amyotrophic lateral sclerosis

European Journal of Neurology, 2020
The prognostic value of serum neurofilament light chain (sNfL), a biomarker of neurodegeneration, compared to other prognostic factors of amyotrophic lateral sclerosis (ALS) at the time of diagnosis, remains unclear.
E. Thouvenot, C. Demattei, S. Lehmann, A. Maceski‐Maleska, C. Hirtz, R. Juntas-Morales, N. Pageot, F. Esselin, S. Alphandéry, T. Vincent, W. Camu   +10 more
semanticscholar   +1 more source

Amyotrophic Lateral Sclerosis: Review

Seminars in Neurology, 2015
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting the upper and lower motor neurons. The lifetime risk of developing ALS is estimated at 1:350 for men and 1:500 for women, higher for those who have served in the military. The diagnosis remains clinical with electrodiagnostic support.
Johnny S, Salameh, Robert H, Brown, James D, Berry   +2 more
openaire   +2 more sources

Amyotrophic Lateral Sclerosis Model

2018
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects upper and lower motor neurons in the brain and the spinal cord. Due to the progressive neurodegeneration, ALS leads to paralysis and death caused by respiratory failure 2-5 years after the onset of symptoms. There is no effective cure available.
Yumiko, Azuma, Ikuko, Mizuta, Takahiko, Tokuda, Toshiki, Mizuno   +3 more
openaire   +2 more sources

Effect of High‐Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis

Annals of Neurology, 2019
Weight loss has been identified as a negative prognostic factor in amyotrophic lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases survival.
A. Ludolph, J. Dorst, J. Dreyhaupt, Jochen H Weishaupt, J. Kassubek, Ulrike Weiland, T. Meyer, S. Petri, A. Hermann, A. Emmer, J. Grosskreutz, T. Grehl, D. Zeller, M. Boentert, B. Schrank, J. Prudlo, A. Winkler, S. Gorbulev, F. Roselli, Joachim Schuster, L. Dupuis   +20 more
semanticscholar   +1 more source

Amyotrophic lateral sclerosis

Postgraduate Medicine, 1981
Amyotrophic lateral sclerosis, a progressive disease characterized by selective loss of upper and lower motor neurons, equals or exceeds multiple sclerosis in incidence. The clinical and pathologic features are discussed, as well as practical management strategies.
L L, Amico, J P, Antel
openaire   +2 more sources

Amyotrophic lateral sclerosis: translating genetic discoveries into therapies.

Nature reviews genetics, 2023
F. Akçimen, Elia R Lopez, J. Landers, A. Nath, A. Chiò, Ruth Chia, B. Traynor   +6 more
semanticscholar   +1 more source

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

Medicinal research reviews (Print), 2018
Over the past decades, a multitude of experimental drugs have been shown to delay disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but failed to show efficacy in human clinical trials or are still waiting for ...
M. Jaiswal
semanticscholar   +1 more source

Amyotrophic Lateral Sclerosis Microgenomics

Physical Medicine and Rehabilitation Clinics of North America, 2005
Amyotrophic lateral sclerosis (ALS) is a degenerative disease of the cen-tral nervous system (CNS) characterized by progressive weakness from de-generation of motor neurons [1]. The main clinical features of weaknessare focal onset at any region of the neuraxis, a mix of upper and lowermotor neuron dysfunction, and contiguous spread over time [2] (Fig.
John, Ravits, Patrick, Laurie, Brad, Stone   +2 more
openaire   +2 more sources