Results 351 to 360 of about 242,580 (385)

Introducing Amyotrophic lateral sclerosis.

Archives italiennes de biologie, 2011
Introducing ALS at present times leads to re-define the concept of motor neuron selectivity which characterizes this disorder. In fact, multiple systems including skin, liver, and bone marrow are altered in ALS patients. The motor neuron is still the focus of the disorder and the extended pathology did not modify the concept of ALS as a devastating ...
Silani V, Meininger V, FORNAI, FRANCESCO
openaire   +4 more sources

Juvenile amyotrophic lateral sclerosis

The Indian Journal of Pediatrics, 2006
Juvenile amytrophic lateral sclerosis (JALS) is a type of motor neuron disease presenting before 25 years of age. It is characterized by a combination of upper and lower motor signs. It may be familial or sporadic. We are reporting a sporadic case of JALS with onset of symptoms at 4 years of age. Diagnostic criteria and a brief review of literature are
Anju, Aggarwal, , Shashiraj
openaire   +2 more sources

Familial amyotrophic lateral sclerosis

Muscle & Nerve, 2002
AbstractThe increasing complexity of the pathways implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS) has stimulated intensive research in many directions. Genetic analysis of familial ALS has yielded six loci and one disease gene (SOD1), initially suggesting a role for free radicals in the disease process, although the ...
Collette K, Hand, Guy A, Rouleau
openaire   +2 more sources

Ameliorating Amyotrophic Lateral Sclerosis

New England Journal of Medicine, 2010
A newly implicated molecular pathway in skeletal muscle regulates the formation of the neuromuscular junction and is implicated in a mouse model of amyotrophic lateral sclerosis.
openaire   +2 more sources

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Science, 2006
M. Neumann, Deepak M. Sampathu, L. Kwong, Adam C. Truax, Matthew C. Micsenyi, T. T. Chou, J. Bruce, T. Schuck, M. Grossman, C. Clark, L. McCluskey, B. Miller, E. Masliah, I. Mackenzie, H. Feldman, W. Feiden, H. Kretzschmar, J. Trojanowski, V. Lee   +18 more
semanticscholar   +1 more source

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Nature, 1993
D. Rosen, T. Siddique, D. Patterson, D. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J. O'Regan, H. Deng, Z. Rahmani, A. Krizus, D. McKenna-Yasek, A. Cayabyab, Sandra M. Gaston, R. Berger, Rudolph E. Tanzi, John J. Halperin, B. Herzfeldt, Raymond Van den Bergh, W. Hung, T. Bird, G. Deng, Donald W. Mulder, C. Smyth, Nigel G. Laing, E. Soriano, M. Pericak-Vance, J. Haines, Guy A Rouleau, James S. Gusella, H. Horvitz, Robert H. Brown   +32 more
semanticscholar   +1 more source

Familial amyotrophic lateral sclerosis

1997
Amyotrophic lateral sclerosis is sporadic in ninety percent of cases and familial (FALS) in ten percent. Both forms of FALS whether transmitted as an autosomal dominant (DFALS) or as an autosomal recessive (RFALS) trait is genetically heterogeneous. The locus for one form of RFALS maps to chromosome 2q33.
T, Siddique, D, Nijhawan, A, Hentati
openaire   +2 more sources

El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders, 2000
B. Brooks, Robert G. Miller, M. Swash, T. Munsat   +3 more
semanticscholar   +1 more source

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Biochemical and Biophysical Research Communications - BBRC, 2006
T. Arai, M. Hasegawa, H. Akiyama, K. Ikeda, T. Nonaka, H. Mori, D. Mann, K. Tsuchiya, Mari Yoshida, Y. Hashizume, Tatsuro Oda   +10 more
semanticscholar   +1 more source

The new (Version 9) American Joint Committee on Cancer tumor, node, metastasis staging for cervical cancer

Ca-A Cancer Journal for Clinicians, 2021
Alexander B Olawaiye
exaly