Results 71 to 80 of about 482,158 (212)

O ensino de introdução à ciência da enfermagem e fundamentos de enfermagem em um currículo integrado: a experiência da escola de enfermagem Ana Néri da Universidade Federal do Rio de Janeiro (EEAN/UFRJ)

Revista Brasileira de Enfermagem, 1985
O trabalho constitui um estudo sobre o ensino da Introdução para Ciência da Enfermagem e Fundamentos de Enfermagem em um currículo integrado, desenvolvido de forma experimental pela EEAN/UFRJ.
Suely de Souza Baptista, Maria de Lourdes Moreira Pereira, Jussara Sauthier   +2 more
doaj  

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

A Pore or not a Pore? Understanding Pore Size Distributions of Non‐Graphitic Carbon and Atomically‐Dispersed M‐N‐C Materials

Advanced Science, EarlyView.
Gassorption analysis of in‐plane functionalized carbons reveals small, uniform ultramicropore signatures as potential artefacts of specific adsorption of the probe gases. Low‐pressure Langmuir fitting links these features to distinct functionalities via adsorption energies, enabling straightforward quantification of otherwise inaccessible surface‐site ...
Simon W. J. Dietzmann, Asad Mehmood, Jian Liang Low, Shu‐Han Wu, Carsten Prinz, Ana Guilherme Buzanich, Jörg Radnik, Paul A. Appel, Franziska Emmerling, Tim‐Patrick Fellinger   +9 more
wiley   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Frequency and awareness of inguinal and genital organ anomalies among men in military age

Urology Research and Practice, 2019
Objective: Early diagnosis and treatment of external genital abnormalities is important for protecting fertility potential in the future. In this cross-sectional study, it was aimed to determine the prevalence, treatment rate, and awareness of inguinal ...
Haluk Söylemez, Murat Atar, Yaşar Bozkurt, Necmettin Penbegül, Ahmet Ali Sancaktutar   +4 more
doaj   +2 more sources

GESTÃO COMPARTILHADA DE ÁGUAS SUBTERRÂNEAS NA CHAPADA DO APODI, ENTRE OS ESTADOS DO CEARÁ E RIO GRANDE DO NORTE

Revista Águas Subterrâneas, 2012
A Agência Nacional de Águas, em parceria com os estados do Ceará e Rio Grande do Norte, conduziu no âmbito de sua Agenda de Aguas Subterrâneas e do Programa Nacional de Águas Subterrâneas (PNAS), estudos nos aquíferos da Chapada do Apodi que resultaram ...
FERNANDO ROBERTO DE OLIVEIRA, FABRICIO BUENO DA FONSECA CARDOSO, JOÃO MANOEL FILHO, ROBERTO KIRCHHEIM, EDILTON FEITOSA, HILDA RENCK TEIXEIRA, PAULO LOPES VARELLA NETO, MARCO GONÇALVES, FLAVIO SOARES DO NASCIMENTO   +8 more
doaj  

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

THE ROLE OF NITRIC OXIDE GENERATION IN HEMODIALYSIS HYPOTENSION: COMPARISON OF HEPARIN WITH PARNAPARIN

Turkish Journal of Nephrology, 2019
BACKGROUND/AIMS: Despite the increasing evidence for the role of nitric oxide (NO) in hemodialysis hypotension, the source of NO is still debated. Heparin stimulates NO production by the cultured human endothelial cells in vitro. The aim of this study is
Bülent ALTUN, Çetin TURGAN, Ünal YASAVUL, Yunus ERDEM, Celalettin USALAN, A.A. KIYKIM, Mustafa ARICI, Özkan DİNLER, Başak OYAN, Şali ÇAĞLAR   +9 more
doaj  

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source