Results 61 to 70 of about 35,817 (208)

MRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors [PDF]

, 2005
MRI and image quantitation play an expanding role in modern drug research, because MRI offers high resolution and non-invasive ability, and provides excellent soft tissue contrast.
Tang, H, Vasselli, JR, Wu, EX
core   +1 more source

Nerve growth factor is sufficient to cause multiple osteoarthritis‐relevant pathological features in naïve murine knee joints

Arthritis &Rheumatology, Accepted Article.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped due to side‐effects in the joints. Knowledge about the biological effects of NGF on joint tissues is limited.
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Influence of anabolic steroids on the health of athletes [PDF]

, 2017
У статті розкрито поняття «стероїди», «анаболічні стероїди». Коротко подано історію застосування анаболічних стероїдів у медицині та спорті. Об’єкт дослідження – здоров’я спортсмена. Мета – виявлення впливу анаболічних стероїдів на здоров’я спортсмена.
Буко, Анастасія Янівна, Неведомська, Євгенія Олексіївна   +1 more
core  

Evidence of the indirect hormonal activity of prohormones using liver S9 metabolic bioactivation and an androgen bioassay [PDF]

, 2008
Prohormones such as dehydroepiandrosterone (DHEA) are steroid precursors that do not show hormonal activity by themselves. Abuse of these prohormones in cattle fattening is hard to prove because of strong in vivo metabolism and the difficulty to detect ...
Bovee, T.F.H., Groot, M.J., Nielen, M.W.F., Peijnenburg, A.A.C.M., Rijk, J.C.W.   +4 more
core   +2 more sources

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Body Image Perception: Adolescent Boys and Avatar Depiction in Video Games [PDF]

, 2016
Research on mass media’s impact on body image has mostly been focused on females thus far. Of the little research that has been done on male body image, most of it has been focused on adult males, and therefore the effect of mass media on adolescent boys’
Raman, Usha
core   +1 more source

Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management. [PDF]

, 2020
Physical activity and exercise training are effective strategies for reducing the risk of cardiovascular events, but multiple studies have reported an increased prevalence of coronary atherosclerosis, usually measured as coronary artery calcification ...
Aengevaeren, VL, Eijsvogels, TMH, Mosterd, A, Möhlenkamp, S, Prakken, NHJ, Sharma, S, Thompson, PD, Velthuis, BK   +7 more
core   +3 more sources

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

Public health awareness and safety of anabolic steroid use among Sports Science Students in Egypt

Discover Public Health
Background People often misuse anabolic-androgenic steroids (AAS) in high, non-therapeutic doses because they help build muscle and make you stronger. Evaluating students’ knowledge, attitudes, and practices is crucial for designing targeted educational ...
Noha M. Elghazally, Rania M. El-Sallamy, Nancy Magdy Hosney Abo-Frekha, Aya M. R. Abd Elghany, Doaa E. Abdeldaim   +4 more
doaj   +1 more source