Results 141 to 150 of about 187,104 (315)

Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study

American Journal of Hematology, EarlyView.
ABSTRACT Diamond–Blackfan Anemia Syndrome (DBAS) is a rare congenital anemia often requiring chronic red blood cell transfusions from infancy. Without appropriate chelation, iron overload develops early and may be severe; however, no data are available on chelation in patients under 3 years of age.
Francesca Torchio, Baptiste Lecalvez, Emanuela Garelli, Coralie Mallebranche, Adriana Carando, Marie‐Pierre Castex, Nathalie Garnier, Marco Zecca, Nathalie Aladjidi, Elisa Bertoni, Arthur Sterin, Maria Licciardello, Anne Sirvent, Antonella Sau, Isabelle Marie, Benedicte Bruno, Lydie M. Da Costa, Franca Fagioli, Paola Quarello, Thierry Leblanc   +19 more
wiley   +1 more source

Anaemia

, 2017
Anaemia is an important problem in the older population. As it is usually mild and insidious in onset, the symptoms of anemia are often overlooked by older adults who attribute their symptoms to an inevitable consequence of ageing while clinicians may ...
Harvey Jay Cohen, Ammon M. Fager
core   +1 more source

Anaemia and associated factors in people living with HIV on ART in Southern Province of Zambia.

PLoS ONE
BackgroundAnaemia remains a significant comorbidity among people living with HIV (PLHIV) on antiretroviral therapy (ART) in Sub-Saharan Africa (SSA), exacerbated by biological, sociocultural, and clinical factors.
Martin Chakulya, Lweendo Muchaili, Hanzooma Hatwiko, Matenge Mutalange, Memory Ngosa, Bislom C Mweene, Geofrey Mupeta, David Chisompola, Marshall C Mubanga, Lukundo Siame, Joreen P Povia, Benson M Hamooya, Sepiso K Masenga   +12 more
doaj   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.

, 2012
The chicken anaemia virus-derived protein Apoptin/VP3 (CAV-Apoptin) has the important ability to induce tumour-selective apoptosis in a variety of human cancer cells. Recently the first human Gyrovirus (HGyV) was isolated from a human skin swab. It shows
Cole, D, Kulasekararaj, A., Malik, F, Odell, E. W., Bullenkamp, J, Tavassoli, M., Gäken, J, Farzaneh, F, Alkhatabi, H., Odell, EW, Alkhatabi, H, Cole, D., Gaeken, J., Bullenkamp, J., Malik, F., Kulasekararaj, A, Farzaneh, F., Tavassoli, M   +17 more
core   +1 more source

Preoperative anaemia

Continuing Education in Anaesthesia Critical Care & Pain, 2013
HANS, Grégory, Jones, Nicola
openaire   +1 more source

Cancer incidence in relatives of British Fanconi Anaemia patients.

, 2008
BACKGROUND: Fanconi anemia (FA) is an autosomal recessive DNA repair disorder with affected individuals having a high risk of developing acute myeloid leukaemia and certain solid tumours. Thirteen complementation groups have been identified and the genes
Ball Jan, Mathew, CG, Tischkowitz, Marc, Hodgson, SV, Hodgson Shirley V, Tischkowitz Marc, Easton, DF, Ball, J, Mathew Christopher G, Mathew, Christopher G.; id_orcid, Tischkowitz, M, Easton Douglas F, Ball, Jan, Hodgson, Shirley V., Easton, Douglas F.   +14 more
core   +1 more source

Subnational mapping for targeting anaemia prevention in women of reproductive age in Ethiopia: A coverage‐equity paradox

Maternal and Child Nutrition
Anaemia in women of reproductive age (WRA) can be effectively addressed if supported by a better understanding of the spatial variations, magnitude, severity and distribution of anaemia.
Bayuh Asmamaw Hailu, Arnaud Laillou, Stanley Chitekwe, Joseph Beyene, Kaleab Baye   +4 more
doaj   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Mixed-methods exploration of knowledge about causes and prevention of anaemia in reproductive-aged women; a two-centre study

BMC Women's Health
Background Reproductive-aged women are disproportionately represented in the high anaemia burden in sub-Saharan Africa. Understanding the knowledge on anaemia among reproductive-aged women represents a significant milestone towards meeting SDG 3.1 and 3 ...
Amanquador Acquah-Keelson, Abigail Agyenda, Joyce Agyeiwaa, Desmond Appau, Diana Baaba Morrison, Olivia Mawunyo Timpo, Joseph Boachie, Patrick Adu   +7 more
doaj   +1 more source