Results 191 to 200 of about 206,353 (256)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Anaemia Prevention Among Adolescent Girls in Lodhran, Punjab, Pakistan: A School-Based Weekly Iron-Folic Acid Supplementation Pilot Program. [PDF]

Nutrients
Kureishy S, Qureshi AS, Ambreen R, Raza S, Roche ML.   +4 more
europepmc   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Haemolytic Anaemia; Beyond Sickle Cell Anaemia: A Case Series of Patients With Paroxysmal Nocturnal Haemoglobinuria in Kenya. [PDF]

Case Rep Hematol
Ong'ondi M, Lavender O, Gathinji M, Bagha Z.   +3 more
europepmc   +1 more source

Epidemiology of Intensive Nutritional Interventions and Restraints in Hospitalizations for Anorexia Nervosa: Annual National Trends of the United States

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Despite the clinical relevance of enteral and parenteral tube feeding and restraint use in anorexia nervosa (AN), national‐level data on their use have remained limited, particularly for total parenteral nutrition (TPN) and percutaneous endoscopic gastrostomy (PEG).
Hiroyasu Ino, Nancy S. Jecker, Yoshiyuki Takimoto, Eisuke Nakazawa   +3 more
wiley   +1 more source

Symptomatic Ferric Carboxymaltose-Induced Hypophosphataemia: A Case Series of 11 Patients. [PDF]

EJHaem
Weerheim M, Korevaar H, Bizino M, Fortrie G, Vrolijk L, Koster T, Karim F.   +6 more
europepmc   +1 more source

Examining Diagnostic Criteria for Atypical Anorexia Nervosa Post Metabolic Bariatric Surgery

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To examine the applicability of current diagnostic criteria for atypical anorexia nervosa (AAN) to patients 1 year post Metabolic Bariatric Surgery (MBS). Method This prospective ongoing cohort study included patients from the multicenter Psychosocial Registry of Obesity Surgery assessed before surgery and 1 year‐post‐MBS.
Eva Conceição, Ricarda Schmidt, Ben Schreglmann, James E. Mitchell, Thomas Mansfeld, Johannes Sander, Florian Seyfried, Stefan Kaiser, Christine Stroh, Arne Dietrich, Anja Hilbert   +10 more
wiley   +1 more source