Results 71 to 80 of about 35,970 (259)

Tocilizumab versus anakinra in COVID-19: results from propensity score matching

Frontiers in Immunology, 2023
BackgroundTocilizumab and anakinra are anti-interleukin drugs to treat severe coronavirus disease 2019 (COVID-19) refractory to corticosteroids. However, no studies compared the efficacy of tocilizumab versus anakinra to guide the choice of the therapy ...
Robin Arcani, Robin Arcani, Florian Correard, Pierre Suchon, Gilles Kaplanski, Gilles Kaplanski, Rodolphe Jean, Raphael Cauchois, Raphael Cauchois, Marine Leprince, Vincent Arcani, Julie Seguier, Benjamin De Sainte Marie, Baptiste Andre, Marie Koubi, Pascal Rossi, Stéphane Gayet, Nirvina Gobin, Victoria Garrido, Joris Weiland, Elisabeth Jouve, Anne-Laure Couderc, Anne-Laure Couderc, Patrick Villani, Patrick Villani, Aurélie Daumas, Aurélie Daumas   +26 more
doaj   +1 more source

Role of Interleukin-1 in Radiation-Induced Cardiomyopathy [PDF]

, 2015
Thoracic X-ray therapy (XRT), used in cancer treatment, is associated with increased risk of heart failure. XRT-mediated injury to the heart induces an inflammatory response leading to cardiomyopathy.
Abbate, Antonio, Alam, Asim, Gewirtz, David A., Marchetti, Carlo, Mauro, Adolfo G, Mezzaroma, Eleonora, Mikkelsen, Ross B, Sharma, Khushboo, Toldo, Stefano, Van Tassell, Benjamin W.   +9 more
core   +3 more sources

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel

Arthritis &Rheumatology, EarlyView.
Objective Vacuoles E1 enzyme X‐linked autoinflammatory somatic syndrome (VEXAS) is a recently identified rare genetic disorder associated with somatic mutations in the UBA1 gene. VEXAS presents with a combination of inflammatory and hematologic manifestations, leading to increased morbidity and mortality.
Arsene Mekinian, Sophie Georgin‐Lavialle, Marcela A. Ferrada, Sinisa Savic, Matthew J. Koster, Olivier Kosmider, Thibault Comont, Mael Heilblig, Juan I. Arostegui, Annmarie Bosco, Rim Bourguiba, Katherine R. Calvo, Catherine Cargo, Chiara Cattaneo, François Chasset, Henrique Coelho, Corrado Campochiaro, Francesca Crisafulli, Stephanie Ducharme‐Benard, Raquel Faria, Franco Franceschini, Micol Frassi, Emma M. Groarke, Carmelo Gurnari, Yervand Hakobyan, Yvan Jamilloux, Ciprian Jurcut, Yohei Kirino, Austin Kulasekararaj, Hiroyoshi Kunimoto, Lauren M. Madigan, Heřman F. Mann, Chiara Marvisi, Marcin Milchert, Sara Morais, Katja Sockel, Francesco Muratore, Hideaki Nakajima, Mrinal M. Patnaik, Luísa Regadas, Marie Robin, Abraham Rutgers, Carlo Salvarani, Anthony M. Sammel, Joerg Seebach, Pierre Sujobert, Alessandro Tomelleri, Geoffrey Urbanski, Frédéric Vandergheynst, Romana Vieira, David S. Viswanatha, Ewa Więsik‐Szewczyk, Elisa Diral, Benjamin Terrier, Bhavisha A. Patel, Pierre Fenaux, Peter C. Grayson, David B. Beck, on behalf of the International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases, Heřman Mann, Benjamin Terrier, François Chasset, Sophie Georgin Lavialle, Alessandro Tomelleri, Campochiaro Corrado, Carlo Salvarani, Francesca Crisafulli, Franco Franceschini, Micol Frassi, Yohei Kirino, Ewa Więsik‐Szewczyk, Marcin Milchert, Raquel Faria, Ciprian Jurcut, Joerg Seebach, Sinisa Savic, David Beck, Lauren Madigan, Matthew Koster, Patnaik Mrinal, Olivier Kosmider, Pierre Sujobert, Juan I. Arostegui, Catherine Cargo, David Viswanatha, Yervand Hagopian, Mael Heilblig, Pierre Fenaux, Thibault Comont, Bruno Alessandro, Chiara Cattaneo, Elisa Diral, Sara Morais, Austin Kulasekarara, Emma Groarke, Katherine Calvo, Patel Bhavisha, Anthony Sammel, Arsene Mekinian, Benjamin Terrier, Marie Robin, Sophie Georgin Lavialle, Katja Sockel, Yvan Jamilloux, Carmelo Gurnari, Henrique Coelho, Romana Vieira, Rim Bourguiba, Marcela Ferrada, Peter Grayson   +111 more
wiley   +1 more source

Anakinra in pediatric acute fulminant myocarditis

Annals of Intensive Care, 2022
Background Acute fulminant myocarditis in children is associated with elevated mortality and morbidity with few advances in its medical management. Here we report a preliminary experience of children treated with IL-1 receptor antagonist associated with ...
Louise Maunier, Ramy Charbel, Virginie Lambert, Pierre Tissières, Simon Mélissa Emre Ramy Caroline Philippe Caroline Sébas Barreault Beggaz Belli Charbel Claude Durand Galeo, Simon Barreault, Mélissa Beggaz, E. Belli, Ramy Charbel, C. Claude, P. Durand, C. Galeotti, S. Hascoet, Virginie Lambert, A. Maltret, Clémence Marais, Louise Maunier, Jordi Miatello, Luc Morin, Louise Othoniel, Bastien Provot, A. Schvartz, Pierre Tissières, Isabelle Van Aershot, Joy Zogby   +24 more
semanticscholar   +1 more source

Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice [PDF]

, 2012
Endoplasmic reticulum (ER) stress and inflammation are important mechanisms that underlie many of the serious consequences of type II diabetes. However, the role of ER stress and inflammation in impaired ischaemia-induced neovascularization in type II ...
A. Amin, D. Henrion, K. Matrougui, M. Galan, M. Kassan, M. Partyka, M. Trebak, P. Kadowitz, S. Belmadani, S.K. Choi   +9 more
core   +3 more sources

Spermidine reproduces the anti‐inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal‐induced inflammation

Arthritis &Rheumatology, Accepted Article.
Background Gout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL)‐1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu Wilson Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

An open label trial of anakinra to prevent respiratory failure in COVID-19

medRxiv, 2020
Introduction The management of pneumonia caused by SARS-CoV-2 should rely on early recognition of the risk for progression to severe respiratory failure (SRF) and its prevention.
E. Kyriazopoulou, P. Panagopoulos, S. Metallidis, G. Dalekos, G. Poulakou, N. Gatselis, E. Karakike, M. Saridaki, G. Loli, A. Stefos, Danai Prasianaki, S. Georgiadou, O. Tsachouridou, V. Petrakis, K. Tsiakos, M. Kosmidou, Vassiliki Lygoura, Maria Dareioti, H. Milionis, I. Papanikolaou, Karolina Akinosoglou, D. Myrodia, A. Gravvani, A. Stamou, T. Gkavogianni, K. Katrini, Theodoros Marantos, Ioannis P Trontzas, K. Syrigos, L. Chatzis, S. Chatzis, Nikolaos Vechlidis, C. Avgoustou, Stamatios Chalvatzis, M. Kyprianou, J. van der Meer, J. Eugen-Olsen, M. Netea, E. Giamarellos‐Bourboulis   +38 more
semanticscholar   +1 more source

Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease e.g. of the lung with potentially devastating clinical consequences.
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Respons Klinis Pemberian Tocilizumab Dibandingkan Anakinra dalam Tata Laksana Artritis Idiopatik Juvenil Sistemik

Sari Pediatri, 2022
Latar belakang. Artritis idiopatik juvenil (AIJ) sistemik merupakan penyakit inflamasi sistemik yang tidak hanya melibatkan sendi tetapi juga keterlibatan sistemik dan merupakan tipe terberat dari AIJ.
Edy Novery, Rizqi Amalia, Dina Muktiarti, Nia Kurniati   +3 more
doaj   +1 more source

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells [PDF]

, 2017
Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease ...
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Qu, Chao, Schipani, Ernestina, Wang, Chun, Xiao, Jianqiu, Xu, Can-Xin   +8 more
core   +2 more sources