Results 71 to 80 of about 22,540 (195)

Anakinra [PDF]

Reactions Weekly, 2021
  +4 more sources

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

Gut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang, Miao‐ying Geng, Ming‐yue Shao, Gang Wang, Zhi‐wei Jiang   +4 more
wiley   +1 more source

A randomized controlled pilot trial of anakinra for hemodialysis inflammation

, 2022
Chronic inflammation is highly prevalent among patients receiving maintenance hemodialysis and is associated with morbidity and mortality. Inhibiting inflammation with anti-cytokine therapy has been proposed but not well studied in this population ...
T. Alp Ikizler, Ikizler, T Alp, Charytan, David M, Alan S. Kliger, Adriana Hung, Dember, Laura M, Mc Causland, Finnian R, Hung, Adriana, Dominic S. Raj, Paul L. Kimmel, David M. Charytan, Regunathan-Shenk, Renu, Landis, J Richard, Renu Regunathan-Shenk, Finnian R. Mc Causland, Jonathan Himmelfarb, Kimmel, Paul L, Laura M. Dember, Jesse Y. Hsu, Kliger, Alan S, Rajnish Mehrotra, Hsu, Jesse Y, Himmelfarb, Jonathan, Raj, Dominic S, J. Richard Landis, Mehrotra, Rajnish   +25 more
core   +1 more source

Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin- associated periodic syndromes

, 2014
Inessa Bachove,1 Christopher Chang2 1Cooper University Hospital, Children's Regional Hospital, Camden, NJ, USA; 2Division of Allergy and Immunology, Thomas Jefferson University, Wilmington, DE, USA Abstract: Anakinra is an interleukin (IL) receptor ...
Bachove I, Chang C
core  

A randomised trial evaluating anakinra in early active rheumatoid arthritis

ObjectiveThe effectiveness of anakinra (interleukin-1 receptor antagonist) in early rheumatoid arthritis (RA) is unknown. We evaluated the efficacy of anakinra (combined with methotrexate) in a randomised clinical trial of early active RA patients ...
Hassell A, Plant M, Richards S, Kowalczyk A, Ibrahim F, Scott DL, Scott IC, Simpson G, Walker D, White-Alao B   +9 more
core   +4 more sources

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis.

PLoS ONE, 2019
Focal and Segmental Glomerulosclerosis (FSGS) is a severe glomerulopathy that frequently leads to end stage renal disease. Only a subset of patients responds to current therapies, making it important to identify alternative therapeutic options.
Michael Boehm, Eva Nora Bukosza, Nicole Huttary, Rebecca Herzog, Christoph Aufricht, Klaus Kratochwill, Christoph A Gebeshuber   +6 more
doaj   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Pilot Study of IL-1 Antagonist Anakinra for Treatment of Endometriosis [PDF]

Renee T Sullender,1 Ravi K Agarwal,2 Marni B Jacobs,1 Jocelyn M Wessels,3 Warren G Foster,3 Sanjay K Agarwal1 1Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Diego, La Jolla, CA, USA; 2University of ...
Agarwal RK, Foster WG, Agarwal SK, Jacobs MB, Sullender RT, Wessels JM   +5 more
core  

Subcutaneous anakinra in the management of refractory MIS-C in France

Frontiers in Pediatrics
IntroductionMultisystemic inflammatory syndrome in children (MIS-C) is a therapeutic emergency and can lead to myocardial dysfunction (17%–75%) and heart failure (52%–53%).
Perrine Dusser, Alexandre Belot, Fanny Bajolle, Charlotte Kevorkian-Verguet, Ulrich Meinzer, Ulrich Meinzer, Frédéric Huet, Soizic Tiriau, Isabelle Kone-paut   +8 more
doaj   +1 more source

Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial Ischemia/Reperfusion Injury

The Scientific World Journal, 2012
Background. Revascularization of infarcted myocardium results in release of inflammatory cytokines mediating myocardial reperfusion injury and heart failure. Blockage of inflammatory pathways dampens myocardial injury and reduces infarct size.
Christina Grothusen, Angelika Hagemann, Tim Attmann, Jan Braesen, Ole Broch, Jochen Cremer, Jan Schoettler   +6 more
doaj   +1 more source