Results 41 to 50 of about 120,880 (301)

Transcutaneous electrical nerve stimulation and analgesia following inguinal hernioplasties – Preliminary report

International Journal of Abdominal Wall and Hernia Surgery, 2019
INTRODUCTION: Inguinal hernioplasty is the most common surgical procedure. Although it is a low-risk surgery, it may present significant postoperative pain. Pharmacological pain relief may result in adverse effects.
Victoria Santa María, Magali Chahdi Beltrame, Sebastian Cirio, Federico Gorganchian   +3 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Efecto de una dosis de lidocaína y ketamina sobre el consumo intraoperatorio de opioides en pacientes sometidas a cirugía ginecológica electiva bajo anestesia general. Estudio piloto aleatorizado y controlado con placebo [PDF]

, 2016
Background and goal of study: there is evidence that perioperative intravenous ketamine and lidocaine reduce postoperative pain, postoperative opioids consumption, shortens hospital stay and accelerates intestinal function recovery.
Vilches Arenas, Ángel
core  

Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization [PDF]

, 2018
Administration of local anesthetics is one of the most effective pain control techniques for postoperative analgesia. However, anesthetic agents easily diffuse into the injection site, limiting the time of anesthesia. One approach to prolong analgesia is
Alonso, Silvia del Valle, Castro, Simone R., Couto, Verônica M., Dantzger, Darlene D., de Paula, Eneida, Feas, Daniela Agustina, Guilherme, Viviane A., Igartúa, Daniela, Machado, Daisy, Prieto, Maria Jimena, Ribeiro, Lígia N.M., Silva, Camila M.G.   +11 more
core   +1 more source

Improving the use of the 'COUGH' bundle in Surgical High Dependency Unit, Ninewells Hospital, Dundee [PDF]

, 2020
Developing respiratory complications postoperatively is one of the major determinants of longer hospital stay, morbidity, mortality and increased healthcare costs. The incidence of postoperative respiratory complications varies from 1% to 23%. Given that
Hilton-Christie, Sharon, Livie, Jennifer, Livie, Victoria   +2 more
core   +2 more sources

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

POSTOPERATIVE ANALGESIA;

The Professional Medical Journal, 2012
Objective: To compare the effects after caudal bupivacaine alone and bupivacaine-tramadol in young children with inguinalhernia repair. Setting: Department of Paediatric Anaesthesia, Children Hospital Complex, Multan. Period: August 2008 to May 2009.Material and methods: A total of 100 children aged between 2-5 years were included in the study. Results:
ASMA SAMEE, M. SHAFIQUE TAHIR, NADEEM AHMAD KHAN, Muhammad Masood, Muhammad Yousaf, Salman Waris   +5 more
openaire   +3 more sources

Preventive analgesia for postoperative pain control: a broader concept

Local and Regional Anesthesia, 2014
Nalini Vadivelu,1 Sukanya Mitra,2 Erika Schermer,3 Vijay Kodumudi,4 Alan David Kaye,5 Richard D Urman61Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA; 2Department of Anesthesia and Intensive Care, Government Medical ...
Vadivelu N, Mitra S, Schermer E, Kodumudi V, Kaye AD, Urman RD   +5 more
doaj  

Nerve block using local anesthetic and dexmedetomidine in patients undergoing functional endoscopic sinus surgery

Ain Shams Journal of Anesthesiology, 2022
Background The main anesthetic goal in the postoperative period of functional endoscopic sinus surgery (FESS) is early and pain-free recovery, with return of protective airway reflex. The aim of this study is to evaluate the role of dexmedetomidine as an
Tarek Abdel hay Mostafa, Mohammed Osama Tommom, Naglaa Khalil Khalil   +2 more
doaj   +1 more source