Results 11 to 20 of about 347,788 (376)

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain [PDF]

Pharmacological Research. 104750 (2020), 2020
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from the first intracellular loop of ...
arxiv   +1 more source

The analgesia of methoxyflurane [PDF]

Canadian Anaesthetists’ Society Journal, 1963
A preliminary study was made of analgesia produced by methoxyflurane in oxygen in eleven patients undergoing surgery. Methoxyflurane was found to be safe and excellent as an analgesic agent. An associated drowsiness was also noticed, similar to that seen in the postanaesthetic period of conventional methoxyflurane anaesthesia.
Ronald S. Lambie, Ronald S. Lambie
openaire   +3 more sources

A prospective, multicentre, observational cohort study of analgesia and outcome after pneumonectomy [PDF]

, 2011
Background Meta-analysis and systematic reviews of epidural compared with paravertebral blockade analgesia techniques for thoracotomy conclude that although the analgesia is comparable, paravertebral blockade has a better short-term side-effect profile ...
Berry, C., Bowler, G. M. R., Brown, V., Cook, D., Davies, P., Dhallu, T., Foley, M., Forrest, M., Gilbert, M., Giri, R., Kendall, J., Knowles, A., Latter, J., Lee, G., Macfie, A., McCulloch, B., Mills, R., Mitchell, J., Naidu, Babu V., Nel, L., Nelson, J., Pardeshi, L., Pearce, A. C., Powell, E. S., Smith, F. Gao (Fang Gao), Stockwell, M., Strachan, L., Woodall, N., Woodward, D.   +28 more
core   +1 more source

Association Between Burst-Suppression Latency and Burst-Suppression Ratio Under Isoflurane or Adjuvant Drugs With Isoflurane Anesthesia in Mice

Frontiers in Pharmacology, 2021
The same doses of anesthesia may yield varying depths of anesthesia in different patients. Clinical studies have revealed a possible causal relationship between deep anesthesia and negative short- and long-term patient outcomes. However, a reliable index
Di Wang, Di Wang, Qingchen Guo, Di Liu, Xiang-Xi Kong, Zheng Xu, Yu Zhou, Yan Su, Feng Dai, Hai-Lei Ding, Hai-Lei Ding, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao   +13 more
doaj   +1 more source

Postoperative Pain Management After Sternotomy In Off-Pump Coronary Artery Bypass Graft (CABG) Surgery - A Comparative Study Between NSAID (Diclofenac Sodium) and Opioid (Pethidine)

Bangabandhu Sheikh Mujib Medical University Journal, 2011
Background: Traditionally, postoperative pain has been managed either reactively with drugs given as needed or proactively with continuous infusion of analgesics. Objectives:The present prospective comparative study was carried out to find difference in
Kamrul Hasan, Zerzina Rahman, Ayesha Sultana, Najib Ahsan   +3 more
doaj   +1 more source

Distributed Real-Time Emulation of Formally-Defined Patterns for Safe Medical Device Control [PDF]

EPTCS 36, 2010, pp. 158-177, 2010
Safety of medical devices and of their interoperation is an unresolved issue causing severe and sometimes deadly accidents for patients with shocking frequency. Formal methods, particularly in support of highly reusable and provably safe patterns which can be instantiated to many device instances can help in this regard. However, this still leaves open
arxiv   +1 more source

Effect of continuous intraoperative infusion of methoxamine on renal function in elderly patients undergoing gastrointestinal tumor surgery: a randomized controlled trial

BMC Anesthesiology, 2020
Background Acute renal injury (AKI) caused by hypotension often occurs in elderly patients after gastrointestinal tumor surgery. Although vasoactive drugs can increase effective filtration pressure, they may increase renal vascular resistance and reduce ...
Xiaowei Guo, Jie Hu, Hanbing Xiao, Tianyu Liu, Zheng Niu, Min Wang, Dunyi Qi   +6 more
doaj   +1 more source

Using LOR Syringe Probes as a Method to Reduce Errors in Epidural Analgesia -- a Robotic Simulation Study [PDF]

arXiv, 2023
Epidural analgesia involves injection of anesthetics into the epidural space, using a Touhy needle to proceed through the layers in the epidural region and a "loss of resistance" (LOR) syringe to sense the environment stiffness. The anesthesiologist's case experience is one of the leading causes of accidental dural puncture and failed epidural - the ...
arxiv  

The Antitumor Peptide ERα17p Exerts Anti-Hyperalgesic and Anti-Inflammatory Actions Through GPER in Mice

Frontiers in Endocrinology, 2021
Persistent inflammation and persistent pain are major medical, social and economic burdens. As such, related pharmacotherapy needs to be continuously improved.
Christophe Mallet, Christophe Mallet, Ludivine Boudieu, Ludivine Boudieu, Sylvain Lamoine, Sylvain Lamoine, Catherine Coudert, Catherine Coudert, Yves Jacquot, Alain Eschalier, Alain Eschalier   +10 more
doaj   +1 more source

Neuropeptide Y and its involvement in chronic pain [PDF]

2017,Neuroscience, 2017
Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments.
arxiv   +1 more source