Results 301 to 310 of about 402,046 (367)

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade   +4 more
wiley   +1 more source

Mucoadhesive Polyvinyl Alcohol Film Containing Fridericia chica Extract for Mucositis Treatment: Pharmacological Evaluation and Active Compounds Release

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Oral mucositis is a frequent and painful complication of cancer therapy with limited effective options. This study evaluated a mucoadhesive polyvinyl alcohol (PVA) film containing 2.5% Fridericia chica extract as a novel strategy. The formulation was characterized for antioxidant activity, phenolic and flavonoid content, and reactive species ...
Ilza Maria de Oliveira Sousa   +12 more
wiley   +1 more source

Current Perspectives on Remifentanil-PCA for Labor Analgesia: A Narrative Review. [PDF]

open access: yesMedicina (Kaunas)
Vovk Racman P   +2 more
europepmc   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

open access: yesChemistry &Biodiversity, EarlyView.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper   +6 more
wiley   +1 more source

Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence. [PDF]

open access: yesWorld J Urol
Perros I   +5 more
europepmc   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

open access: yesChemistryEurope, EarlyView.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña   +5 more
wiley   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

open access: yesChemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju   +4 more
wiley   +1 more source

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