Results 311 to 320 of about 402,046 (367)

Effect of combined dexmedetomidine with ropivacaine in transversus thoracis plane block on surgical stress response during cardiopulmonary bypass surgery: a randomized controlled trial. [PDF]

Front Cardiovasc Med
Huang L, Chen Y, Xu X, Zeng F, Li C, Fu H.   +5 more
europepmc   +1 more source

Unveiling the Potential of a New β‐Cyclodextrin‐Suxibuzone Conjugate in Proteasome Regulation

ChemMedChem, EarlyView.
A novel β‐cyclodextrin‐suxibuzone conjugate enhances chymotryptic‐like activity of the 20S proteasome in a dose‐dependent manner. It remains stable and is internalized in SH‐SY5Y cells for 24 h. These findings suggest therapeutic potential for proteasome‐related disorders through targeted proteasome activation.
Noemi Bognanni, Stefania Zimbone, Maria Laura Giuffrida, Giuseppe Di Natale, Danilo Milardi, Graziella Vecchio, Valeria Lanza   +6 more
wiley   +1 more source

Comparison of Ultrasound-Guided Pericapsular Nerve Group Block Versus Intravenous Ketamine for Positional Pain Management Before Spinal Anesthesia in Patients Who Underwent Hip Fracture Surgery: A Randomized Controlled Trial. [PDF]

Med Sci Monit
Cakmak G, Ciftci B, Vahapoglu A, Tunay A, Erden V.   +4 more
europepmc   +1 more source

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

ChemMedChem, EarlyView.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch, Hernan A. Bazán, Nicolas G. Bazan, Bhattacharjee Surjyadipta, Julio Alvarez‐Builla, Beatriz de Pascual‐Teresa   +5 more
wiley   +1 more source

Effect of quadratus lumborum block combined with butorphanol-based PCIA on postoperative analgesia and early recovery in patients undergoing colorectal cancer surgery. [PDF]

Am J Transl Res
Jiang Q, Xiang D, Wang H, Zhang Y.
europepmc   +1 more source

Bilateral mental nerve block in lower lip laceration repair: A case report. [PDF]

Int J Surg Case Rep
Arihaihi O, Niyongabo F, Veldhuis LI, Epiu I.   +3 more
europepmc   +1 more source

Determination of the median effective dose of chloroprocaine in labour: preliminary results [PDF]

, 2015
Anssens, Sarah, Coppens, Marc, De Hert, Stefan, Deschepper, Ellen, Wouters, Patrick   +4 more
core   +1 more source

Routine use of intravenous acetaminophen safely enhances pain control after minimally invasive hepatectomies: a retrospective cohort study. [PDF]

BMC Surg
Furuya K, Nakajima M, Tokumitsu Y, Shindo Y, Matsui H, Kimura Y, Nakagami Y, Watanabe Y, Tomochika S, Maeda N, Iida M, Takahashi H, Ioka T, Ueno T, Nagano H.   +14 more
europepmc   +1 more source

Postpartum continuous epidural analgesia on pain, sleep quality, and emotional state in childbearing women: a randomized controlled trial. [PDF]

Front Med (Lausanne)
Zhang J, Li J, Zhang X, Wu J.
europepmc   +1 more source

Effect of liposomal bupivacaine for the suprascapular nerve combined with axillary nerve block on postoperative analgesia in patients undergoing shoulder surgery: a randomized, observer-blinded trial. [PDF]

BMC Anesthesiol
Xu M, Gao H, Zheng R, Wu H, Yuan K, Li J, Wang Q.   +6 more
europepmc   +1 more source