Results 201 to 210 of about 51,375 (229)
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Non-Narcotic Analgesics — Their use and Abuse
Journal of The Royal Naval Medical Service, 1972AbstractThere is now available a considerable range of non-narcotic analgesics; many are still supplied in the form of compound tablets although true synergy is rare in clinical pharmacology. The value of these analgesics is discussed and their many other uses outlined.
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Pemedolac: a novel and long-acting non-narcotic analgesic.
The Journal of Pharmacology and Experimental Therapeutics, 1989Pemedolac [cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)-pyrano [3,4-b]indole-1-acetic acid; AY-30,715] exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. In each of the animal models used the analgesic potency of pemedolac was defined by an ED50 of 2.0 mg/kg p.o.
T T, Chau, B M, Weichman
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Effect of non-narcotic analgesics on anticoagulant-induced hypoprothrombinemia in rats
Experientia, 1972Chez le rat, un traitement a l'acide acetylsalicilique, au salicilate sodique et au phenylbutazone fait remonter le taux de protrombine abaisse par la bishydrocoumarine.
Zofia Z. Zawidzka +2 more
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Non-Narcotics and Co-Analgesics
1984Aspirin and other non-steroidal antiinflammatory drugs (NSAIDs) and paracetamol are the most important of the non-narcotic analgesics. As simple analgesics they have equal potency but paracetamol is generally better tolerated, particularly with regard to gastrointestinal side-effects1.
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Animal pharmacology of oxapadol (MD 720111), a new non-narcotic analgesic
Experientia, 1980Oxapadol is a non-narcotic analgesic with an unusual chemical structure. It possesses analgesic activity in 4 species similar to that of other non-narcotic reference analgesics. It also shows antipyretic and antiinflammatory effects and in the analgesic dose range is devoid of undesirable neurological, gastro-intestinal and cardiovascular side-effects.
A. Coston, Jalfre M, Mocquet G
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Investigations on the specificity of the so-called analgesic activity of non-narcotic drugs
European Journal of Pharmacology, 1970Abstract Trazodone, pentobarbital, thiopental, chlorpromazine, propionylpromazine and chlordiazepoxide were tested intravenously in mice for acute toxicity and for effects on phenylquinone writhing, motor coordination and righting reflex. Barbiturates and chlordiazepoxide suppressed the righting reflex at doses corresponding to 1 3 of LD50 ...
B. Silvestrini, E. Quadri
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Suprofen: the Pharmacology and Clinical Efficacy of a New Non-narcotic Peripheral Analgesic
Clinics in Rheumatic Diseases, 1984Suprofen is a potent, peripherally-acting, non-narcotic analgesic agent. The mechanism of action of the compound involves inhibition of prostaglandin biosynthesis and, perhaps, direct antagonism of the peripheral, pain inducing actions of prostaglandins, bradykinin and other pain mediators. Suprofen at a dose of 200 mg appears to be equal or greater in
Robert J. Capetola +3 more
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