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Topical Analgesics: Pharmacology and Clinical Applications. [PDF]

open access: yesAnesthesiology
Sisignano M, Rice ASC, Geisslinger G.
europepmc   +1 more source
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Narcotic analgesics

Inflammopharmacology, 2023
There is documentation of the use of opium derived products in the ancient history of the Assyrians: the Egyptians; in the sixth century AD by the Roman Dioscorides; and by Avicenna (980-1037). Reference to opium like products is made by Paracelsus and by Shakespeare.
W. Watson Buchanan   +3 more
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Analgesic Nephropathy

Survey of Anesthesiology, 1998
Many questions about analgesic nephropathy (AN) lack clear-cut answers. We present available evidence for and against proposed answers to many of these questions. These include: (1) Is acetaminophen (AC) nephrotoxic when taken as the sole analgesic? (2) Is the combination of acetylsalicylic acid (ASA) and AC more nephrotoxic than AC taken alone, and if
de Broe, Marc E., Elseviers, Monique M.
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Analgesics

Current Medical Research and Opinion, 2001
Analgesics such as acetaminophen (paracetamol), acetylsalicyclic acid and non-steroidal anti-inflammatory drugs are effective in the treatment of migraine attacks. Comparative studies indicate that their efficacy is similar or slightly inferior to sumattriptan, a specific antimigraine drug.
H C, Diener, V, Limmroth
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Analgesic Pharmacology: II. Specific Analgesics

Journal of the American Academy of Orthopaedic Surgeons, 2004
Methods of treatment are different for acute and chronic pain. For acute pain, analgesics such as nonsteroidal anti-inflammatory drugs and opiates are commonly used, sometimes combined with regional anesthesia, such as peripheral nerve block or peridural local anesthesia.
William J, Phillips, Bradford L, Currier
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Topical Analgesics

Physical Medicine and Rehabilitation Clinics of North America, 2020
Topical analgesics are a growing area of clinical interest, given improvements in formulation drug delivery and local delivery of medicine, limiting risk for potential adverse systemic effects. Topical analgesics include medications for acute and chronic pain, such as musculoskeletal pain disorders, including sprains and strains; neuropathic pain; and ...
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Analgesics

2010
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are often incriminated in hypersensitivity reactions leading to anaphylaxis. Two populations are at the high risk of developing such reactions: patients with asthma and those with urticaria.
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Opioid Analgesics

Veterinary Clinics of North America: Small Animal Practice, 2000
Opioids are useful and potent drugs for the management of pain in small animal patients. They have a wide therapeutic index and can be given by a number of different routes. Some of these techniques (e.g., epidural and intraarticular) allow for the production of profound analgesia in a localized area of the body while limiting the dose and the side ...
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Analgesic Resveratrol?

Antioxidants & Redox Signaling, 2008
Resveratrol, a red wine and grape-derived phytoalexin, possesses diverse biochemical and physiological functions that are relevant to human health and disease. The emergent properties of resveratrol have forced us to rethink the biomedical significance of the wine culture.
BERTELLI, ALBERTO   +5 more
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Combination Analgesics

The American Journal of Medicine, 1984
Six rationales for using combination analgesics are identified, but most combinations are formulated with two rationales in mind: enhancement of analgesia and reduction of adverse effects by combining two analgesics with different mechanisms of action. Acetaminophen and aspirin are the mainstays of oral analgesic combinations.
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