Results 111 to 120 of about 580,719 (297)

Digital servo controller [PDF]

, 1974
A system, for generating a signal to control the rotation of a shaft supporting an antenna so that the antenna is rotated the shortest angular distance from a present angular position to a new desired angular position, was described. The system comprises
Byrne, F.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Droplet-Based Microfluidics in Single-Bacterium Analysis: Advancements in Cultivation, Detection, and Application

Biosensors
Microorganisms exhibit remarkable diversity, making their comprehensive characterization essential for understanding ecosystem functioning and safeguarding human health. However, traditional culture-based methods entail inherent limitations for resolving
Haiyan Ma, Yuewen Zhang, Ren Shen, Yanwei Jia   +3 more
doaj   +1 more source

Two New Families of Floating FDNR Circuits

Journal of Electrical and Computer Engineering, 2010
Two new configurations for realizing ideal floating frequency-dependent negative resistor elements (FDNR) are introduced. The proposed circuits are symmetrical and are realizable by four CCII or ICCII or a combination of both.
Ahmed M. Soliman, Ramy A. Saad
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Model-Order Reduction of Multistage Cascaded Models for Digital Predistortion

IEEE Journal of Microwaves
This paper explores the benefits of utilizing multistage cascaded (CC) behavioral models for digital predistortion (DPD) linearization of wideband high-efficiency power amplifiers (PAs).
Raul Criado, Wantao Li, William Thompson, Gabriel Montoro, Kevin Chuang, Pere L. Gilabert   +5 more
doaj   +1 more source

System for memorizing maximum values [PDF]

The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer.
Bozeman, Richard J., Jr.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Single-Trim Highly Accurate Frequency Reference Techniques

IEEE Open Journal of the Solid-State Circuits Society
This article describes a CMOS frequency reference system that achieves quartz-crystal-oscillator-rivaling frequency accuracy and power consumption across a temperature range of 228 °C, with low degradation over lifetime.
Thomas J. Hoen, Alexander S. Delke, Yanyu Jin, Jos Verlinden, Bram Nauta, Anne-Johan Annema   +5 more
doaj   +1 more source