Results 121 to 130 of about 585,344 (349)

Single-Trim Highly Accurate Frequency Reference Techniques

IEEE Open Journal of the Solid-State Circuits Society
This article describes a CMOS frequency reference system that achieves quartz-crystal-oscillator-rivaling frequency accuracy and power consumption across a temperature range of 228 °C, with low degradation over lifetime.
Thomas J. Hoen, Alexander S. Delke, Yanyu Jin, Jos Verlinden, Bram Nauta, Anne-Johan Annema   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

GPU-Based Implementation of Pruned Artificial Neural Networks for Digital Predistortion Linearization of Wideband Power Amplifiers

IEEE Journal of Microwaves
This paper presents a feature selection technique based on $\ell _{1}$ regularization to select the most relevant weights of artificial neural networks (ANNs) for digital predistortion (DPD) linearization of wideband radio-frequency (RF) power amplifiers
Wantao Li, Raul Criado, William Thompson, Gabriel Montoro, Kevin Chuang, Pere L. Gilabert   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Twin-capacitive shaft angle encoder with analog output signal [PDF]

, 1977
A precision capacitive shaft encoder providing a dc signal corresponding to the angular position of a shaft is described. Two variable capacitances are coupled in tandem by a rotatable shaft.
Hruby, R. J., Wilson, R. L.
core   +1 more source

Real-time gap-free dynamic waveform spectral analysis with nanosecond resolutions through analog signal processing. [PDF]

Nat Commun, 2020
Konatham SR, Maram R, Romero Cortés L, Chang JH, Rusch L, LaRochelle S, Guillet de Chatellus H, Azaña J.   +7 more
europepmc   +1 more source

Data Compression Versus Signal Fidelity Tradeoff in Wired-OR Analog-to-Digital Compressive Arrays for Neural Recording

, 2023
Pumiao Yan, Arash Akhoundi, Nishal P. Shah, Pulkit Tandon, Dante G. Muratore, E. J. Chichilnisky, Boris Murmann   +6 more
openalex   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

In vivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest

, 2023
Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Mutsumi Okamura, Shingo Dan, Masaya Imoto, Kazuhiro Irie   +6 more
openalex   +1 more source