Results 81 to 90 of about 163,099 (316)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Ruler vs. the Apple II/FIRST system analysis of analog signals in classical conditioning [PDF]

, 1982
Beverly Marshall‐Goodell, Bernard G. Schreurs, I. Gormezano   +2 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Droplet-Based Microfluidics in Single-Bacterium Analysis: Advancements in Cultivation, Detection, and Application

Biosensors
Microorganisms exhibit remarkable diversity, making their comprehensive characterization essential for understanding ecosystem functioning and safeguarding human health. However, traditional culture-based methods entail inherent limitations for resolving
Haiyan Ma, Yuewen Zhang, Ren Shen, Yanwei Jia   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Model-Order Reduction of Multistage Cascaded Models for Digital Predistortion

IEEE Journal of Microwaves
This paper explores the benefits of utilizing multistage cascaded (CC) behavioral models for digital predistortion (DPD) linearization of wideband high-efficiency power amplifiers (PAs).
Raul Criado, Wantao Li, William Thompson, Gabriel Montoro, Kevin Chuang, Pere L. Gilabert   +5 more
doaj   +1 more source

A strain-gauge conditioner/analog-to-digital converter for acquisition of multiple analog signals [PDF]

, 1980
A. W. Price, Alan J. Fridlund, Stephen C. Fowler   +2 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

GPU-Based Implementation of Pruned Artificial Neural Networks for Digital Predistortion Linearization of Wideband Power Amplifiers

IEEE Journal of Microwaves
This paper presents a feature selection technique based on $\ell _{1}$ regularization to select the most relevant weights of artificial neural networks (ANNs) for digital predistortion (DPD) linearization of wideband radio-frequency (RF) power amplifiers
Wantao Li, Raul Criado, William Thompson, Gabriel Montoro, Kevin Chuang, Pere L. Gilabert   +5 more
doaj   +1 more source

Analog VLSI signal processing: Why, where, and how? [PDF]

, 1994
Eric A. Vittoz
openalex   +1 more source