Results 181 to 190 of about 75,159 (257)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Learned adaptive properties for mitigation of weight perturbations in embedded spiking networks. [PDF]

Front Neurosci
Luca S, Xiao TP, Chance FS, Agarwal S, Teeter C, Chapman GW.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

HASCom: A Heterogeneous Affective-Semantic Communication Framework for Speech Transmission. [PDF]

Sensors (Basel)
Yu Z, Zhu T, Hossain MA, Zbarna Z, Wang L.   +4 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Design and Fabrication of a Chitosan-Based Diaphragm Digital Stethoscope for Heart Sound Acquisition. [PDF]

Micromachines (Basel)
Rivas Ebner MC, Kim SW, Yu G, Ackah E, Jeong HW, Byun KM, Seok YS, Choi SH.   +7 more
europepmc   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Optical logic convolutional neural network. [PDF]

Sci Adv
Zhang W, Li J, Zhang S, Wu B, Wang Y, Zhou H, Dong J, Zhang X.   +7 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

The Solar Wind Electron (SWE) Instrument for the Interstellar Mapping and Acceleration Probe Mission. [PDF]

Space Sci Rev
Skoug RM, Schultz TB, Venhaus DM, Amaya CE, Choedon T, Christian ER, Crosier RD, De Los Santos A, Fernandes PA, Ford JJ, Gkioulidou M, Hanley JJ, Harvey DS, Hoeper PJ, Kubeczka PW, Liu Y, Martinez JP, McComas DJ, Mohr HD, Nunez C, Pacheco TR, Pope SE, Rodriguez H, Sandoval BF, Schiferl CM, Schwadron NA, Spalsbury LC, Seitz DN, Smith RM, Steinberg JT, Storms SA, Toczynski W, Tyler YD, Vigil VJ.   +33 more
europepmc   +1 more source