Results 201 to 210 of about 72,590 (262)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

High-speed 0.22 THz communication system with 84 Gbps for real-time uncompressed 8K video transmission of live events. [PDF]

Nat Commun
Liu K, Feng Y, Han C, Chang B, Chen Z, Xu Z, Li L, Zhang B, Wang Y, Xu Q.   +9 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Striking a Balance With Business and Engineering Content in Biomedical Engineering Capstone Design. [PDF]

J Biomech Eng
Eberhardt AW.
europepmc   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Optoelectronics Interfaces for a VLC System for UHD Audio-Visual Content Transmission in a Passenger Van: HW Design. [PDF]

Sensors (Basel)
Del Valle Morales CI, Betancourt Perlaza JS, Torres Zafra JC, Martinez-Sarriegui I, Sánchez-Pena JM.   +4 more
europepmc   +1 more source

DICOM encoding of annotation and montage data for waveform recordings. [PDF]

Clin Neurophysiol
Halford JJ, Brinkmann BA, Rampp S, Rémi J, Poznikoff S, Nilsen KB, Ehrenberg JA, Winkler S.   +7 more
europepmc   +1 more source

Patient and Operator Experiences with Conventional Rubber Dam and OptiDam: A Randomized Clinical Trial. [PDF]

J Int Soc Prev Community Dent
Binqali RF, Alghamdi AM, Aloufi MS, Alharbi SA, Bukhari OM, Alsamman RM.   +5 more
europepmc   +1 more source

Multimodal Wearable Monitoring of Exercise in Isolated, Confined, and Extreme Environments: A Standardized Method. [PDF]

Methods Protoc
Hejda J, Sokol M, Leová L, Volf P, Tonner J, Hsu WC, Lin YJ, Sugiarto T, Rozložník M, Kutílek P.   +9 more
europepmc   +1 more source