Results 71 to 80 of about 179,740 (256)
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
An Analogue Front-End Architecture for Software Defined Radio [PDF]
A Software Defined Radio (SDR) is a radio receiver and/or transmitter, whose characteristics can to a large extent be defined by software. Thus, an SDR can receive and/or transmit a wide variety of signals, supporting many different standards.
Arkesteijn, Vincent J. +2 more
core +2 more sources
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Digital pulse-shape discrimination of fast neutrons and gamma rays
Discrimination of the detection of fast neutrons and gamma rays in a liquid scintillator detector has been investigated using digital pulse-processing techniques.
Alexander +27 more
core +1 more source
Digitally tuned analogue integrated filters usingR-2R ladder
A new technique for designing digitally tuned frequency selective analogue integrated circuits is proposed. The technique incorporates the R-2R ladder as a circuit element into the circuit design to provide precise frequency characteristics that can be tuned over a wide range. Two filters are described to illustrate the proposed approach.
Al-Zaher, H., Ismail, M.
openaire +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Distributive inverse semigroups and non-commutative Stone dualities [PDF]
We develop the theory of distributive inverse semigroups as the analogue of distributive lattices without top element and prove that they are in a duality with those etale groupoids having a spectral space of identities, where our spectral spaces are not
Lawson, Mark V, Lenz, Daniel H
core
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Concrete materials : series 1 [PDF]
This book provides the various usages of materials for producing good concrete. It will appeal to several major audiences. It is a compilation of works which using different types of material in concrete.
core

