Results 91 to 100 of about 46,394,056 (362)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
The expanding role of the Indonesian military [PDF]
The Indonesian military appears to be taking advantage of a weak president and unpopular police to try and regain some of the internal security functions that it lost as part of the country’s democratisation process.
Institute for Policy Analysis of Conflict
core
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Changes in the Concept of Public Greenery on the Basis of an Analysis of Czech Municipal Financing
SHS Web of Conferences, 2017 The public sector is an inseparable part of every economy. It performs a number of functions such as providing public services, environmental protection, defense, security, education, health, justice and many others.
Rousek Pavel, Hašková Simona
doaj +1 more source
The current status of the Papuan pro-independence movement [PDF]
Examines the aims, capacity, leadership and activities of both the armed units of the Free Papua Organisation (Organisasi Papua Merdeka, OPM) and the various political groupings supporting independence in Papua and abroad. Executive summary Indonesia’s
Institute for Policy Analysis of Conflict
core
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Rational Competitive Analysis [PDF]
Proceedings of IJCAI-2001, 2001 Much work in computer science has adopted competitive analysis as a tool for decision making under uncertainty. In this work we extend competitive analysis to the context of multi-agent systems. Unlike classical competitive analysis where the behavior of an agent's environment is taken to be arbitrary, we consider the case where an agent's environment ...
arxiv
Rapid method to obtain virgin olive oil for acidity determination.
Grasas y Aceites, 1999 A rapid and simple method to obtain, from olive samples, enough quantity of oil to determine acidity grade is proposed. From paste samples of milled olives, different fraction are separated to be centrifugated during 5 minutes at 4500 r.p.m.
F. Martínez +5 more
doaj +1 more source
The Sulu archipelago and the Philippine Peace Process [PDF]
This paper examines the factors behind the reluctance of the ruling elites in the Sulu islands, in the Philippines, to join a region that will be dominated by the Moro Islamic Liberation Front (MILF) from central Mindanao.
Institute for Policy Analysis of Conflict
core
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source