Results 181 to 190 of about 69,874,824 (396)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Retracted: Numerical Solution of Nonlinear Fredholm Integrodifferential Equations by Hybrid of Block-Pulse Functions and Normalized Bernstein Polynomials

Abstract and Applied Analysis, 2014
Abstract and Applied Analysis
doaj   +1 more source

Buckling of slender composite concrete‐filled steel columns

Journal of Civil Engineering and Management, 2010
The paper presents the analysis of the experimental data of 1817 on concrete‐filled steel tubes ‐ CFSTs. These results are compared with the predicted results of the load‐bearing capacity of calculations of slender elements according to the methods ...
C. Douglas Goode, Artiomas Kuranovas, Audronis Kazimieras Kvedaras   +2 more
doaj  

ANALYSIS OF QUANTITATIVE INHERITANCE OF BODY SIZE IN MICE. II. GENE ACTION AND SEGREGATION [PDF]

, 1956
C. K. Chai
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A Significance Test for Component Analysis [PDF]

, 1937
Paul G. Hoel
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

The Analysis, Identification and Treatment of an Amber Artifact

Archeomatica, 2013
This study describes the identification and treatment of an amber necklace, which came into the conservation lab  of Conservation Art Service, with an opaque bloom caused by a previous cleaning with a household ammonia cleanser.
Niccolo Caldararo
doaj  

A DEVELOPMENTAL ANALYSIS OF THE LETHAL MUTANT L(2)GL OF DROSOPHILA MELANOGASTER BASED ON CYTOPHOTOMETRIC DETERMINATION OF NUCLEAR DESOXYRIBONUCLEIC ACID (DNA) CONTENT [PDF]

, 1957
Robert M. Welch
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source