Results 181 to 190 of about 72,747,221 (383)

Qualitative Analysis and Documentary Method: In International Educational Research

, 2010
Weller Wivian, Pfaff, Nicolle, Bohnsack, Ralf   +2 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Historical aspects of arising and features of activity of startup companies: accounting and economic aspects

Проблеми теорії та методології бухгалтерського обліку, контролю і аналізу, 2016
The history of arising and development of the concept of «startup company» have been studied and the importance of their activities have been determined.
S.F. Legenchuk, G.V. Pilipchuk
doaj  

Analysis of Intracorporeal Compared with Extracorporeal Urinary Diversion After Robot-assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium

, 2013
Kamran Ahmed, Shahid Khan, Matthew H. Hayn, Piyush K. Agarwal, Ketan K. Badani, Mevlana Derya Balbay, Erik P. Castle, Prokar Dasgupta, Reza Ghavamian, Khurshid A. Guru, Ashok K. Hemal, Brent K. Hollenbeck, Adam S. Kibel, Mani Menon, Alexandre Mottrie, Kenneth G. Nepple, John Pattaras, James O. Peabody, Vassilis Poulakis, Raj S. Pruthi, Joan Palou Redorta, Koon Ho Rha, Lee Richstone, Matthias Saar, Douglas S. Scherr, Stefan Siemer, Michael Stöeckle, Eric Wallen, Alon Z. Weizer, Peter Wiklund, Timothy G. Wilson, Michael Woods, Muhammad Shamim Khan   +32 more
openalex   +2 more sources

Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects [PDF]

, 2018
Rocío Barragán, Óscar Coltell, Olga Portolés, Eva M. Asensio, José V. Sorlí, Carolina Ortega‐Azorín, José I. González, Carmen Sáiz, Rebeca Fernández-Carrión, José M. Ordovás, Dolores Corella   +10 more
openalex   +1 more source

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.

Molecular biology and evolution, 2016
Sudhir Kumar, G. Stecher, K. Tamura
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source