Results 251 to 260 of about 46,394,056 (362)

Completeness of reporting of simulation studies on responder analysis methods and simulation performance: a methodological survey. [PDF]

BMJ Open
Chu X, Chu DK, Ren J, Brignardello-Petersen R, Yang K, Guyatt GH, Lehana T.   +6 more
europepmc   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Adverse Effects Associated With Ibuprofen Use After Major Orthopaedic Surgeries-A Detailed Statistical Analysis Plan for the PERISAFE Randomized Clinical Trial. [PDF]

Acta Anaesthesiol Scand
Laursen CCW, Lunn TH, Hägi-Pedersen D, Olsen MH, Kappel A, Jakobsen T, Pedersen NA, Thougaard T, Graungaard BK, Bjerno T, Hollænder PB, Runge C, Yilmaz M, Eljaja SB, Therkelsen ASN, Steiness J, Gasbjerg KS, Thybo K, Lange KHW, Brorson S, Varnum C, Lindberg-Larsen M, Overgaard S, Mathiesen O, Jakobsen JC.   +24 more
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Mendelian randomization reveals limited causal effects of genetic variants on cervical cancer risk: insights from immune cell populations. [PDF]

Discov Oncol
Zhang Z, Fu F, Zhuang S.
europepmc   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ANALYSIS OF MODERN INVENTIONS FOR IMPROVING THE HUMAN FRAME. [PDF]

Robert Beales
openalex   +1 more source

Metabolic syndrome and bladder cancer risk: a comprehensive evidence synthesis combining bibliometric and meta-analysis approaches. [PDF]

BMC Urol
Yuan Y, Liu T, Yao Y, Ma Q, Sun L, Zhang G.   +5 more
europepmc   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Quadratus lumborum block versus caudal block in paediatric surgeries: a protocol for systematic review and meta-analysis. [PDF]

BMJ Open
Wu H, Huang J.
europepmc   +1 more source