Results 261 to 270 of about 48,044,330 (330)

Whole-genome sequencing bulked segregant analysis uncovered FW7, a Fusarium wilt resistance gene masked by epistasis in octoploid strawberry. [PDF]

Plant Genome
Vachev MV, Bjornson M, Pincot DDA, Famula RA, Lovell JT, Harder AM, Handley LH, Grimwood J, Brukental H, Lòpez CM, Cole GS, Feldmann MJ, Knapp SJ.   +12 more
europepmc   +1 more source

Transportation in the Ante-Bellum South: An Economic Analysis

, 1905
Ulrich B. Phillips
openalex   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

VaMiAnalyzer: an open source, Python-based application for analysis of 3D in vitro vasculogenic mimicry assays. [PDF]

BMC Bioinformatics
Moore SPG, Zou A, Zhang X, Jonathan OC, Lang D, Zhang C.   +5 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

The multidimensional role of SLC16A4 in hepatocellular carcinoma in silico analysis: prognostic significance, metabolic pathways, and immune microenvironment regulation. [PDF]

Eur J Med Res
Jiang L, Shen Y, Feng Z, Wang Y, Zhu Y, Shen Y, Peng Q.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour. [PDF]

Cancer Immunol Immunother
Panagiotidis K, Owens S, Finegan G, Horgan N, Tsavdaridis S, Kennedy S, Floudas A.   +6 more
europepmc   +1 more source

A BIOLOGICAL ANALYSIS OF PELLAGRA-PRODUCING DIETS

, 1919
E. V. McCollum, Nina Simmonds, Helen T. Parsons   +2 more
openalex   +1 more source