Results 261 to 270 of about 993,426 (339)

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block. [PDF]

Genet Res (Camb)
Wang T, Miao X, Xia Y.
europepmc   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder. [PDF]

BMC Psychiatry
Luo Z, Chen Y, Xu Y, Qiu X, Li W, Hu Z, Lu H, Wang C, Lan X, Mai S, Liu G, Zhang F, Chen X, You Z, Zeng Y, Liang Y, Chen Y, Zhou Y, Ning Y.   +18 more
europepmc   +1 more source

Insights into the role of dynamical features in protein complex formation: The case of SARS-CoV-2 spike binding with ACE2. [PDF]

Comput Struct Biotechnol J
Grassmann G, Miotto M, Alessandrini F, Bo' L, Ruocco G, Milanetti E, Giansanti A.   +6 more
europepmc   +1 more source

An Open-Path Eddy-Covariance Laser Spectrometer for Simultaneous Monitoring of CO₂, CH₄, and H₂O. [PDF]

Sensors (Basel)
Meshcherinov V, Gazizov I, Pravuk B, Kazakov V, Zenevich S, Spiridonov M, Gazizov S, Suvorov G, Kuricheva O, Lebedev Y, Vinogradov I, Rodin A.   +11 more
europepmc   +1 more source

But how does it smell? An investigation of olfactory bulb size among living and fossil primates and other euarchontoglirans

The Anatomical Record, EarlyView.
Analysis of cranial endocast data of 181 extant and 41 fossil species from Euarchontoglires shows that there was a reduction in olfactory bulb size in Crown Primates, but that there were also subsequent reductions in various other primate clades (Anthropoidea, Catarrhini, Platyrrhini, crown Cercopithecoidea, Hominoidea).
Madlen Maryanna Lang, Mary Teresa Silcox, Łucja Fostowicz‐Frelik, Adam Lis, Sergi López‐Torres, Gabriela San Martin‐Flores, Ornella C. Bertrand   +6 more
wiley   +1 more source

The relationship between form and function of the carnivore mandible

The Anatomical Record, EarlyView.
Abstract Dietary morphology diversified extensively in Carnivoraformes (living Carnivora and their stem relatives) during the Cenozoic (the last 66 million years) as they evolved to capture, handle, and process new animal and plant diets. We used 3D geometric morphometrics, mechanical advantage, and finite element analysis to test the evolutionary ...
Charles J. Salcido, P. David Polly
wiley   +1 more source

RBF Neural Network-Aided Robust Adaptive GNSS/INS Integrated Navigation Algorithm in Urban Environments. [PDF]

Sensors (Basel)
Wang J, Li R, Tu R, Zhang G, Hong J, Li F.   +5 more
europepmc   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

The Anatomical Record, EarlyView.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source