Results 161 to 170 of about 221,955 (289)

A Perspective on Software Intelligence for Autonomous Transformations in Biomedical Data and Knowledge. [PDF]

Learn Health Syst
Navale V.
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement. [PDF]

Sci Data
Vadadokhau U, Soliman M, Castillon L, Pastor Muñoz P, Id L, Natraj Gayathri S, Srivastava A, Runeberg T, González-Armijos T, Šapovalovaitė K, Sakalauskaite M, Adhikari S, Abe O, Tohmola T, Li H, Sundaresan S, Vesikukka H, Roininen J, Zangene E, Soliymani R, Tuomivaara ST, Schwämmle V, Saei AA, Varjosalo M, Jafari M.   +24 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Ten simple rules for building a collaborative coding culture. [PDF]

PLoS Comput Biol
Zuckerman AL, Faber S, Shen K, McIntosh AR, Juavinett AL.   +4 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

CartograPlant: bridging genomic, phenotypic, and environmental data to advance plant resilience and eco-evolutionary insight. [PDF]

Genetics
Lind BM, Cobo-Simón I, Myles M, Barrett G, Grau E, Ramnath R, Savitsky V, Wegrzyn JL.   +7 more
europepmc   +1 more source

Understanding Software Development in an Open Source Context:Network Analysis of Source Code Repositories. [PDF]

, 2016
Open Source Software (OSS) created a paradigm shift within the software engineering field prompting further research to understand how mature, industry grade, software can be produced in an online milieu with distributed and lightly managed developers contributing source code in their free time.
openaire   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

The NIAID Discovery Portal: a unified search engine for infectious and immune-mediated disease datasets. [PDF]

mSystems
Tsueng G, Bullen E, Czech C, Welzel D, Collares L, Lin J, Rodolpho E, Qazi Z, Acosta N, Mayer LM, Venkatachari S, Mitrović Vučičević Z, Burman PN, Jain D, DiGiovanna J, Giovanni M, Lin A, Van Panhuis W, Hughes LD, Su AI, Wu C.   +20 more
europepmc   +1 more source