Results 191 to 200 of about 221,955 (289)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Research Code Sharing in Support of Gold Standard Science. [PDF]

J Diabetes Sci Technol
Klonoff DC, Espinoza J, Mader JK, Heinemann L, Cobelli C, Kerr D, Kovatchev B, Najafi B, Prahalad P, Zheng Y, Shao MM, Scheideman AF, DuNova AY, Kohn M, Umpierrez GE, Wong TY, Abdel Malek A, Agus MSD, Ahn DT, AlSaad R, Al-Sofiani ME, Armstrong D, Arnold MA, Bee YM, Bequette BW, Bellazzi R, Cengiz E, Chase JG, Chen H, Chen JY, Cichosz SL, Cinar A, Clements MA, Close KL, Cuadros J, Contreras I, Datta G, Dhatariya K, Doyle FJ, Drincic A, Facchinetti A, Fleming GA, Foreman J, Gabbay MAL, Gutierrez-Osuna R, Healey E, Hoang TD, Jacobs PG, Kulzer B, La Belle J, Lee AY, Lee CS, Lee WA, Liepmann D, Maahs D, Mathioudakis N, Meo SA, Metwally AA, Misra S, Mohan V, Moon SJ, Raeder H, Rhee C, Rhee EJ, Scheinker D, Shah VN, Sheng B, Snyder MP, Sode K, Spanakis EK, Svensson J, Vaswani N, Vareth M, Vehi J, Wallia A, Waki K, Wang T, Williams E, Wolf RM, Wong JC, Yeshiwas S, Zilbermint M, Shah SN.   +82 more
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

A dataset of DIMACS formulas derived from Kconfig models for research on highly configurable software. [PDF]

Data Brief
Heradio R, Cerrada C, Abad I, Aranda E, Escribano JJ, Fernandez-Amoros D.   +5 more
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Are we researching the right questions? Bibliometric analysis of undergraduate nursing thesis alignment with Peru's health priorities. [PDF]

Front Res Metr Anal
Cuya-Zevallos C, Lazo-Barreda D, Cardeña-Valverde M, Chocano-Rosas T, Salazar T, Corvacho N, Monroy C, Pinto A, Veleto A.   +8 more
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

The Reactome Knowledgebase 2026. [PDF]

Nucleic Acids Res
Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, Griss J, Hogue GFJ, Li NT, Matthews L, May B, Milacic M, Mohammadi H, Petryszak R, Rothfels K, Shamovsky V, Stephan R, Tiwari K, Weiser J, Wright A, Gillespie M, Wu G, Stein L, Hermjakob H, D'Eustachio P.   +24 more
europepmc   +1 more source

A Novel CsYABBY3‐CsAS1 Feedback Loop Coordinates Trichome Differentiation and Cannabinoid Biosynthesis in Cannabis sativa L.

Advanced Science, EarlyView.
A novel transcriptional module involving CsYABBY3 and CsAS1 is identified to regulate cannabinoid biosynthesis and trichome development. These factors mutually activate each other and form a protein complex via a conserved residue, acting synergistically to amplify metabolic flux through a coordinate feed‐forward mechanism.
Xuewen Zhu, Yaolei Mi, Xue Cao, Weiqiang Chen, Pucheng Fan, Jing Wang, Yiming Zhang, Wei Yang, Huihua Wan, Shanshan Chen, Xiangxiao Meng, Jun Li, Shuo Shen, Mingkun Huang, Xiaoyu Zhang, Ming Luo, Shilin Chen, Zhichao Xu, Wei Sun   +18 more
wiley   +1 more source

Childhood Cancer Data Initiative Participant Index: Mapping Pediatric Cancer Data to Facilitate Cross-Study Integrated Analysis. [PDF]

JCO Clin Cancer Inform
Jagu S, Guidry Auvil JM, Cunningham MD, Jimenez RF, Ferguson ML, Smith MA, Hawkins DS, Alonzo TA, Beeles T, Widemann BC, Kibbe WA, Reaman GH.   +11 more
europepmc   +1 more source