Results 91 to 100 of about 39,209 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Exploring new constraints on Kähler moduli space of 6d N $$ \mathcal{N} $$ = 1 supergravity
Journal of High Energy PhysicsWe propose new constraints for 6d (1, 0) supergravity theories based on consistency conditions on the Kähler moduli spaces of their 5d reductions. The requirement that both the metric and the BPS string tensions in the Kähler moduli space are positive ...
Hee-Cheol Kim, Cumrun Vafa
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Normalized Space Alignment: A Versatile Metric for Representation Analysis
Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2Under ...
Danish Ebadulla +2 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Geometric Aspects of Mixed Quantum States Inside the Bloch Sphere
Quantum ReportsWhen studying the geometry of quantum states, it is acknowledged that mixed states can be distinguished by infinitely many metrics. Unfortunately, this freedom causes metric-dependent interpretations of physically significant geometric quantities such as
Paul M. Alsing +3 more
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A Union of Euclidean Metric Spaces is Euclidean
Discrete Analysis, 2016 A Union of Euclidean Metric Spaces is Euclidean, Discrete Analysis 2016:14, 15pp. A major theme in metric geometry concerns conditions under which it is possible to embed one metric space into another with small distortion. More precisely, if $M_1$ and $
Konstantin Makarychev, Yury Makarychev
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Calculus, fractals, and analysis on metric spaces
, 2010 This article was prepared in connection with the 2009 Barnett lecture at the University of Cincinnati, and deals with various classes of fractal sets and analysis on them.
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A few aspects of analysis on metric spaces
, 2002 These are some basic notes concerning Holder and Lipschitz classes on metric spaces.
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