Results 51 to 60 of about 84,417,931 (147)
Publication of registration studies for veterinary medicine in peer-reviewed academic journals
Veterinary EvidenceMuch clinically applied research undertaken by research and development departments of pharmaceutical companies is used to support the registration of veterinary medicinal products but is only made publicly available in summary form by the authorisation ...
Jonathan Elliott
doaj +1 more source
The Jacobson topology of Prim* L¹(G) for exponential Lie groups [PDF]
, 2007 Ungermann O. The Jacobson topology of Prim* L¹(G) for exponential Lie groups.
Ungermann, Oliver
core
Operators of finite rank in unitary representations of exponential Lie groups [PDF]
, 1982 Poguntke D. Operators of finite rank in unitary representations of exponential Lie groups. Mathematische Annalen.
Poguntke, Detlev
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Organising general practice for care homes: a multi-method study
Health and Social Care Delivery ResearchBackground General practice provides first-line National Health Service care for around 400,000 care home residents. Good primary care can enhance residents’ health and well-being and optimise use of hospital services.
Barbara Hanratty +7 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Voices in BioethicsPhoto ID 345549 © Jonathan Mulkey | Dreamstime.com Abstract Emerging DNA marketplace startups aim to empower individuals with greater control and potential profit-sharing over their genetic data, but they face ethical tensions in navigating ...
Alexis Walker
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source