Results 101 to 110 of about 2,009,025 (329)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Peer Review #2 of "dxpr: an R package for generating analysis-ready data from electronic health records—diagnoses and procedures (v0.2)"

, 2021
Yi‐Ju Tseng, Hsiang-Ju Chiu, Chun Chen, G Chen, N Khan, R Walker, H Quan, J Denny, M Ritchie, M Basford, J Pulley, L Bastarache, K Brown-Gentry, D Wang, D Masys, D Roden, D Crawford, A Dima, D Dediu, A Elixhauser, C Steiner, D Harris, R Coffey, R Fleurence, L Curtis, R Califf, R Platt, J Selby, J Brown, W Hersh, G Hripcsak, D Albers, C-Y Hsieh, C-C Su, S-C Shao, S-F Sung, S-J Lin, Yang Kao, Y-H Lai, Ec-C, P Jensen, L Jensen, S Brunak, Aew Johnson, T Pollard, L Shen, L Lehman, M Feng, M Ghassemi, B Moody, P Szolovits, Anthony Celi, L Mark, R, M Menendez, V Neuhaus, C Van Dijk, D Ring, R Miotto, C Weng, B Moore, S White, R Washington, N Coenen, A Elixhauser, R-Sig-Db) Wickham, H Mller, K, W Raghupathi, V Raghupathi, P Ryan, D Springate, R Parisi, I Olier, D Reeves, E Kontopantelis, M Tsai, M Lin, C Lee, Y Yang, W Chen, G Chang, Tsai Y Te, P Chen, Y Tsai, Y-J Tseng, Cami Goldmann, D Demaria, A Mandl, K, Y-J Tseng, A Demaria, D Goldmann, K Mandl, Y-J Tseng, R-F Hu, S-T Lee, Y-L Lin, C-L Hsu, S-W Lin   +99 more
openalex   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Generate Analysis-Ready Data for Real-world Evidence: Tutorial for Harnessing Electronic Health Records With Advanced Informatic Technologies (Preprint)

, 2023
Jue Hou, Rachel Zhao, Jessica Gronsbell, Yucong Lin, Clara-Lea Bonzel, Qingyi Zeng, Sinian Zhang, Brett K. Beaulieu‐Jones, Griffin M. Weber, Thomas Jemielita, Shuyan Sabrina Wan, Chuan Hong, Tianrun Cai, Jun Wen, Vidul Ayakulangara Panickan, Kai‐Li Liaw, Katherine P. Liao, Tianxi Cai   +17 more
openalex   +1 more source

Towards Sentinel-2 Analysis Ready Data: a Swiss Data Cube Perspective

IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium, 2018
Earth Observations Data Cubes (EODC) are a new paradigm revolutionizing the way users can interact with Earth Observations (EO) data. They can provide access to large spatio-temporal data in analysis ready format. Systematic and regular provision of Analysis Ready Data (ARD) can significantly reduce the burden on EO data users by minimizing the time ...
Giuliani, Gregory, Chatenoux, Bruno, Honeck, Erica Cristine, Richard, Jean-Philippe   +3 more
openaire   +3 more sources

Analisis Kesiapan Guru IPA dalam Implementasi Kurikulum 2013 di SMP Negeri Se- Kecamatan Stabat [PDF]

, 2018
The study of Science Teacher Readiness Analysis in 2013 Curriculum Implementation in this Public Middle School aims to find out: the readiness of Junior High School science teachers in preparing learning by implementing the 2013 curriculum and the ...
Safitri, L. (Layil)
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source