Results 31 to 40 of about 1,828,537 (231)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

P4344An example that big data analysis is ready for the prime time [PDF]

European Heart Journal, 2019
Abstract Introduction Data about the epidemiology of valvular heart disease (VHD) is scarce. The increasing aging of the population may cause an augmented prevalence of VHD, with a great number of comorbidities that conveys a higher surgical risk.
R Munoz, A Sanchez, M Giganto, C Cortina, M Sarrion, L Mora, M Dominguez, D Vaqueriza, C Beltran, V Suberviola, E Gomez   +10 more
openaire   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Randomized Kaczmarz for Rank Aggregation from Pairwise Comparisons

, 2016
We revisit the problem of inferring the overall ranking among entities in the framework of Bradley-Terry-Luce (BTL) model, based on available empirical data on pairwise preferences. By a simple transformation, we can cast the problem as that of solving a
Borkar, Vivek S., Karamchandani, Nikhil, Mirani, Sharad   +2 more
core   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Characterizing the Landscape of Musical Data on the Web: State of the Art and Challenges [PDF]

, 2017
Musical data can be analysed, combined, transformed and exploited for diverse purposes. However, despite the proliferation of digital libraries and repositories for music, infrastructures and tools, such uses of musical data remain scarce.
d'Aquin, Mathieu, Daga, Enrico, Daquino, Marilena, Gangemi, Aldo, Holland, Simon, Laney, Robin, Mulholland, Paul, Penuela, Albert Merono   +7 more
core   +3 more sources

Decision support system for the selection of an ITE or a BTE hearing aid [PDF]

, 2013
The purpose of this research is to mine a large set of heterogeneous audiology data to create a decision support system (DSS) to choose between two hearing aid types (ITE and BTE aid).
Anwar, Muhammad Naveed, Oakes, Michael Philip   +1 more
core   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Analysis-ready satellite data mosaics from Landsat and Sentinel-2 imagery

MethodsX, 2023
Today's enormous amounts of freely available high-resolution satellite imagery provide the demand for effective preprocessing methods. One such preprocessing method needed in many applications utilizing optical satellite imagery from the Landsat and Sentinel-2 archives is mosaicking. Merging hundreds of single scenes into a single satellite data mosaic
Hans Ole Ørka, Jãnis Gailis, Mathias Vege, Terje Gobakken, Kenneth Hauglund   +4 more
openaire   +3 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source