Results 241 to 250 of about 943,761 (315)

Purpose in life and depressive symptoms: An individual-participant meta-analysis of >500,000 participants across six world regions. [PDF]

J Affect Disord
Sutin AR, Luchetti M, Stephan Y, Karakose S, Mansor N, Terracciano A.   +5 more
europepmc   +1 more source

Derived products and analytical scripts for "Seasonal to decadal dynamics of supraglacial lakes on debris-covered glaciers in the Khumbu Region, Nepal"

Lucas Zeller, Daniel McGrath, Scott McCoy, Jonathan Jacquet   +3 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Alcohol and cannabis use predicted by affect-urgency interactions in everyday life. [PDF]

Clin Psychol Sci
Dora J, McCabe CJ, Schultz ME, Lee CM, Shoda Y, Patrick ME, Smith GT, King KM.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Operationalizing a research-oriented learning healthcare system across covered entities: cross-institutional strategies and innovations. [PDF]

Npj Health Syst
Huerta TR, Bartlett CW, Alain G, Bentley T, Bradford CR, Bridges JF, Chakravarti A, Farag AA, Gerhardt CA, Gorman T, Grannis SJ, Huang Y, Johnson JA, Kraguljac NV, Li L, Ma Q, Mathur P, Mays M, McAlearney AS, Mendonca EA, Moroi SE, Ning X, Odden C, Phelps L, Smoyer WE, Strouse R, Walker C, Zhang P, Blakaj DM.   +28 more
europepmc   +1 more source

Machine learning to optimize precision in the analysis of randomized trials: A journey in pre-specified, yet data-adaptive learning. [PDF]

Clin Trials
Balzer LB, van der Laan MJ, Petersen ML.
europepmc   +1 more source

Risk for Acute Care Utilization in Housing-Insecure Adults: A National Study of a Hot Spotter Program in the US Veterans Health Administration. [PDF]

Med Care
Blonigen DM, Macia KS, Raikov I, Yoon J, Weber J.   +4 more
europepmc   +1 more source

Medicaid Disenrollment Among Young Adults With and Without Complex Medical Conditions. [PDF]

JAMA Pediatr
Cliff BQ, Sinha S, Cross DA, Hickey E, Kirschner K, Caskey R.   +5 more
europepmc   +1 more source