Results 81 to 90 of about 943,761 (315)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Boundedness of composition operators on general weighted Hardy spaces of analytic functions [PDF]

open access: green, 2020
Pascal Lefèvre   +3 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Data analytics [PDF]

open access: yes, 2019
Data analytics have emerged in recent years as a family of overlapping, competing and hybridising products and practices. They have been championed by technology companies, academics, business users and governments alike, and in a short period of time have earned business developers and adopters billions of pounds in revenue and unprecedented levels of
Shepherd, Ifan D. H., Hearne, Gary
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Initial Coefficient Bounds for Bi-Close-to-Convex and Bi-Quasi-Convex Functions with Bounded Boundary Rotation Associated with q-Sălăgean Operator

open access: yesMathematics
In this article, through the application of the q-Sălăgean operator associated with functions characterized by bounded boundary rotation, we propose a few new subclasses of bi-univalent functions that utilize the q-Sălăgean operator with bounded boundary
Prathviraj Sharma   +3 more
doaj   +1 more source

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