Results 111 to 120 of about 935,562 (293)

LLM-Supported Manufacturing Mapping Generation [PDF]

Transactions on Graph Data and Knowledge
In large manufacturing companies, such as Bosch, that operate thousands of production lines with each comprising up to dozens of production machines and other equipment, even simple inventory questions such as of location and quantities of a particular ...
Schmidt, Wilma Johanna, Grangel-González, Irlan, Paschke, Adrian, Kharlamov, Evgeny   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Lower comorbidity scores and severity levels in Veterans Health Administration hospitals: a cross-sectional study

BMC Health Services Research
Background Previous studies found that documentation of comorbidities differed when Veterans received care within versus outside Veterans Health Administration (VHA).
Matthew P. Dizon, Adam Chow, Michael K. Ong, Ciaran S. Phibbs, Megan E. Vanneman, Yue Zhang, Jean Yoon   +6 more
doaj   +1 more source

The Applying ISM/FANP Approach for Appropriate Location Selection of Health Centers [PDF]

Iranian Journal of Management Studies, 2011
The main purpose of this paper is to present a fuzzy multi-criteria decision making (FMADM) model for appropriate location selection of a health center.
Hamid Shahbandarzadeh, Ahmad Ghorbanpour
doaj  

Simultaneous Data Perturbations and Analytic Center Convergence

SIAM Journal on Optimization, 2004
Summary: The central path is an infinitely smooth parameterization of the nonnegative real line, and its convergence properties have been investigated since the mid 1980s. However, the central ''path'' followed by an infeasible-interior-point method relies on three parameters instead of one, and hence is a surface instead of a path.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Hetero-engineering-driven hydroxyl radical generation on ZnO-pillared MXene enables moisture-tolerant methane sensing at ppm level

Carbon Future
Ambient methane detection remains constrained by humidity interference and insufficient sensitivity at room temperature. Compared with standalone Ti3C2Tx MXene, hetero-structured ZnO-pillared Ti3C2Tx MXene was engineered via a simple self-assembly method
Renjie Chen, Yi Xia, Li Yang, Sufang He, Qiuni Zhao, Xiang Li, Yunzhu Wang, Jiyun Gao, Ming Hou, Mingjun Wang, Liexing Zhou, Lan Xiang, Sridhar Komarneni, Shenghui Guo   +13 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Genetic regulation of methylation across East Asian and European populations

Nature Communications
Methylation quantitative trait loci (mQTL) studies have predominantly focused on European populations (EUR), limiting understanding of the genetic regulation of DNA methylation in other populations.
Ruize Liu, Tzu-Ting Chen, Yan Xia, Shu-Chin Lin, Tian Ge, Chia-Yen Chen, Yen-Chen Anne Feng, Hailiang Huang, Yen-Feng Lin   +8 more
doaj   +1 more source