Results 201 to 210 of about 6,042,409 (259)

Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults. [PDF]

Front Aging Neurosci
Callow DD, Rani N, Spira AP, Moghekar A, Wanigatunga S, Pettigrew C, Soldan A, Albert M, Bakker A.   +8 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Gradient-Based Curvature-Only Time-Derivative Coupling for Surface Hopping and Coherent Switching with Decay of Mixing: Application to SO2 and Molecular Tully Models. [PDF]

J Chem Theory Comput
Korsaye FA, González L.
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Modeling of complex physical and biological problems using bi-univalent function calculus. [PDF]

Sci Rep
Saleh ZM, Mostafa AO, Sohaly MA, Madian SM.   +3 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Postoperative Quadriceps Symmetry, Knee Laxity, and Single-Leg Hop Performance in Association with 24-Month Ipsilateral Graft Retear After Anterior Cruciate Ligament Reconstruction: A Cohort Study. [PDF]

Life (Basel)
Kakavas G, Malliaropoulos N, Forelli F.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Where Student Teachers Struggle: Scoring Accuracy and Feedback Quality as a Function of Text Level, Rubric Criteria, and Teacher Traits. [PDF]

Behav Sci (Basel)
Kim H.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source