Results 221 to 230 of about 1,340 (266)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Frozen-Core Analytical Gradients within the Adiabatic Connection Random-Phase Approximation from an Extended Lagrangian. [PDF]
J Chem Theory ComputBates JE, Eshuis H.
europepmc +1 more source
A framework for optimal control of oscillations and synchrony applied to non-linear models of neural population dynamics. [PDF]
Front Comput NeurosciSalfenmoser L, Obermayer K.
europepmc +1 more source
A Geometry of Hamiltonian Mechanics. [PDF]
Entropy (Basel)Elgressy G, Horwitz L.
europepmc +1 more source
Quantum higher-order Fourier analysis and the Clifford hierarchy. [PDF]
Proc Natl Acad Sci U S ABu K, Gu W, Jaffe A.
europepmc +1 more source
Self-Consistent <i>GW</i> via Conservation of Spectral Moments. [PDF]
J Chem Theory ComputBackhouse OJ +3 more
europepmc +1 more source
Optimal Control of Underdamped Systems: An Analytic Approach. [PDF]
J Stat PhysSanders J +2 more
europepmc +1 more source