Results 211 to 220 of about 123,456 (263)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Combined Effect of Per- and Polyfluoroalkyl Substances and Metals on Epigenetic Aging. [PDF]

Toxics
Acquaah F, Obeng-Gyasi E.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Triangulating patient and public involvement in clinical research: a cross-cohort qualitative study. [PDF]

Res Involv Engagem
Hood B, Bojke A, Cooper C, Curtis L, Cruickshank W, Searl S, Searl S, Bojke R, Soulsby I, Walker C, Amezaga J.   +10 more
europepmc   +1 more source

A functional approach to social media assessment: Initial psychometric evaluation of the Social Media Use Functional Assessment. [PDF]

J Appl Behav Anal
Malkin A, Rzeszutek MJ, Moscovitz A, Axenova K, Walker E, Randhawa A, Gunnarsson KF.   +6 more
europepmc   +1 more source

Mapping Practice-Based Signals of Generative AI in Psychiatric Care: Qualitative Study of Korean Psychiatrists' Experiences, Interpretations, and Implementation Priorities. [PDF]

J Med Internet Res
Kim M, An Y, Jeon M, Lee Y, Lahcine OF, Kim H, Lee S, Lee S, Yang JC, Jeon SW, Jung D, Cho CH.   +11 more
europepmc   +1 more source

Information theory and thermal properties of an extended cosine hyperbolic potential model. [PDF]

Sci Rep
Hsu CY, Singh PK, Yusupov Y, Jumanazarov D, Mahariq I, Rajhi AA, Ahmes M.   +6 more
europepmc   +1 more source

Reliability analysis of horseshoe tunnels by radial-based importance sampling method based on complex function displacement solution. [PDF]

PLoS One
Rong Y, Liu Q, Sun Y, Chen X, Zhang X, Li S.   +5 more
europepmc   +1 more source