Results 211 to 220 of about 134,664 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Infection dynamics for fluctuating infection or removal rates regarding the number of infected and susceptible individuals. [PDF]

Infect Dis Model
Park SJ, Jeong SG, Choi MY.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bounds on Hankel Determinants with Fekete-Szegö Parameter for Bazilević Functions. [PDF]

F1000Res
Khaled N, S Juma AR.
europepmc   +1 more source

Can Artificial Intelligence Substitute Dental Public Health Expertise? A Competency-Based Analysis Across Core DPH Domains. [PDF]

J Public Health Dent
AlDukhail S.
europepmc   +1 more source

Translating AI and peer feedback in sustainability-oriented STEM teacher education: pre-service mathematics teachers' uptake, revision, and modeling task-design quality. [PDF]

Front Psychol
Oh S.
europepmc   +1 more source

Associations of Organophosphate Pesticide Metabolite Mixtures with Epigenetic Age Acceleration. [PDF]

J Xenobiot
Davis T, Obeng-Gyasi E.
europepmc   +1 more source

Fine motor skills at preschool age and later academic skills: an indirect-effects analysis involving executive function in high-altitude Tibetan preschoolers. [PDF]

Front Psychol
Wang Y, Su R, Wangdue S, Zhang H, Chen J, Wang C, Zhang Y.   +6 more
europepmc   +1 more source