Results 171 to 180 of about 11,325,593 (240)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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Analytical Methods for Reserpine*

Journal of the American Pharmaceutical Association (Scientific ed.), 1955
The determination of the physical constants of reserpine, methods of analysis, andseparation and identification by paper chromatography are given.These methodsare shown to be applicable to the analysis of the pure compound, crude root ex-tracts, and pharmaceutical preparations.
W H, McMULLEN, H J, PAZDERA, S R, MISSAN, L L, CIACCIO, T C, GRENFELL   +4 more
openaire   +2 more sources

Comparison of analytical methods

Meat Science, 1989
A technique for comparing two analytical methods is presented in this paper. Frequently a new method, generally simpler, faster or less expensive, is compared with a reference method. The deterministic relationships between two methods, subject only to random errors, is first discussed.
L, Körmendy, V, Mihályi, E, Zukál, A, Csiba   +3 more
openaire   +2 more sources

Classification of Analytical Methods

American Industrial Hygiene Association Journal, 1975
The ideal analytical method is one which has been thoroughly evaluated, collaboratively tested by a number of laboratories, and established by long usage. The development of such procedures is time consuming and expensive. However, a classification scheme which recognizes that methods may be used which have not been fully evaluated or collaboratively ...
J V, Crable, R G, Smith
openaire   +2 more sources

Graphical Methods, Analytic

2015
Graphics are a powerful tool for representing and analyzing data. Interactive graphics are ideal for exploratory data analyses, for checking data quality, for investigating assumptions, and for uncovering information. Standard statistical displays (e.g., histograms and scatterplots) are empowered by the addition of interactive features such as direct ...
openaire   +3 more sources