Results 91 to 100 of about 14,778,251 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Analytic Network Process Method

open access: yes, 2011
Diplomová práce se věnuje problematice vícekriteriálního rozhodování, konkrétně pak metodě Analytic Network Process (ANP). Úvodní část obsahuje shrnutí teoretických poznatků potřebných k porozumění metodě a používaných ve zbytku práce.
Lesák, Petr
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Integration of Analytic Network Process in Adaptive Lean and Green Processing

open access: yesChemical Engineering Transactions, 2019
The manufacturing and processing industry have been an important part of the global economy. Many industry players are constantly looking for an alternative to improve their operation and environmental performance to remain competitive in the market. The
Wei Dong Leong   +8 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Analytic network process in economics, finance and management: Contingency factors, current trends and further research [PDF]

open access: yes
[EN] This study explores the recent use of the Analytic Network Process (ANP) in the decision process in the areas of economics, finance and management to identify common contingency factors, current trends, representative studies and directions for ...
Florek-Paszkowska, Anna   +7 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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