Results 21 to 30 of about 25,030 (204)
Universal nonclassicality witnesses for harmonic oscillators
, 2012 It is shown that a nonclassicality witness, whose expectation value can be measured for all quantum states, can be constructed from every nonclassicality filter. This finding leads to a set of universal witnesses, parameterized by only three real numbers,
Kiesel, T., Vogel, W.
core +1 more source
, 2020 We give a new construction of compact Riemannian 7-manifolds with holonomy $G_2$. Let $M$ be a torsion-free $G_2$-manifold (which can have holonomy a proper subgroup of $G_2$) such that $M$ admits an involution $\iota$ preserving the $G_2$-structure ...
Joyce, Dominic, Karigiannis, Spiro
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Non-Hamiltonian generalizations of the dispersionless 2DTL hierarchy
, 2010 We consider two-component integrable generalizations of the dispersionless 2DTL hierarchy connected with non-Hamiltonian vector fields, similar to the Manakov-Santini hierarchy generalizing the dKP hierarchy.
Bogdanov L V +4 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Generic Two-Qubit Photonic Gates Implemented by Number-Resolving Photodetection
, 2009 We combine numerical optimization techniques [Uskov et al., Phys. Rev. A 79, 042326 (2009)] with symmetries of the Weyl chamber to obtain optimal implementations of generic linear-optical KLM-type two-qubit entangling gates.
A. Matthew Smith +7 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source