Results 101 to 110 of about 16,514,849 (251)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

MRI software and cognitive fusion biopsies in people with suspected prostate cancer: a systematic review, network meta-analysis and cost-effectiveness analysis

Health Technology Assessment
Background Magnetic resonance imaging localises cancer in the prostate, allowing for a targeted biopsy with or without transrectal ultrasound-guided systematic biopsy. Targeted biopsy methods include cognitive fusion, where prostate lesions suspicious on
Alexis Llewellyn, Thai Han Phung, Marta O Soares, Lucy Shepherd, David Glynn, Melissa Harden, Ruth Walker, Ana Duarte, Sofia Dias   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tackling chronic depression, adapting and testing the DIALOG+ solution-focused approach for people with long-term depression: the TACK mixed-methods research programme

Programme Grants for Applied Research
Background Long-term (previously termed chronic) depression is associated with significant personal, social and economic consequences often resulting in a poor quality of life for individuals.
Victoria Bird, Philip McNamee, Neil Walker, Yan Feng, Mustapha Mohammed, Esubalew Assefa, Aleksandra Matanov, Lauren Jerome, Andrew Molodynski, Shonagh Scott, Latha Guruvaiah, John Geddes, Sue Collinson, Rose McCabe, Stefan Priebe   +14 more
doaj   +1 more source

Greenness assessment of 174 CEN, ISO, and pharmacopoeia standard methods and their sub-methods used for environmental, food, trace element and pharmaceutical analyses

This work evaluates the greenness of 174 standard methods with a sample preparation step and their 332 sub-method variations from CEN, ISO, and Pharmacopoeias, used in laboratories for environmental/organic, food, trace element, or pharmaceutical ...
Ozkan, Sibel A., Paramee Kumkrong, Marcela A. Segundo, Gumustas, Mehmet, Alberto Chisvert, Maria Llompart, Psillakis, Elefteria, Celeiro, Maria, Bicchi, Carlo, Ruth Godfrey, Cagliero, Cecilia, Marcello Locatelli, Pedersen-Bjergaard, Stig, Enrique Javier Carrasco-Correa, Elefteria Psillakis, Fragoulis Krokos, Carrasco-Correa, Enrique Javier, ÖZKAN, SİBEL AYŞIL, Nemutlu, Emirhan, Juan L. Benede, Francisco Pena-Pereira, Gentili, Alessandra, Mester, Zoltan, Chisvert, Alberto, Tobiszewski, Marek, Sibel A. Ozkan, Marek Tobiszewski, Zoltan Mester, Carlo Bicchi, Alessandra Gentili, Stig Pedersen-Bjergaard, Emirhan Nemutlu, Kumkrong, Paramee, Pena-Pereira, Francisco, Llompart, Maria, Cecilia Cagliero, Segundo, Marcela A., Locatelli, Marcello, Godfrey, A. Ruth, Krokos, Fragoulis, Mehmet Gumustas, Maria Celeiro, Benedé, Juan L.   +42 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Proceso docente educativo en medicina. Sede Universitaria Municipal Mantua. Primer semestre. Curso 2006-2007 Educative-teaching process in medical studies. Municipal University Venue. Mantua. First academic term. Course 2006-2007

Revista de Ciencias Médicas de Pinar del Río, 2007
Se realizó una investigación descriptiva, observacional, analítica e intervencionista con el objetivo de identificar los resultados alcanzados en el Proceso Docente Educativo en el Primer Semestre del Curso 2006-2007, en la Carrera de Medicina, las ...
Juan César Pulido Ramos, Marielys Mons Espinosa, Marisol Roca González, Deylis Miranda Prieto   +3 more
doaj  

Green analytical chemistry in sample preparation

Green chemistry principles have been integrated into various branches of chemistry, including analytical chemistry, in response to growing concerns about the ecosystem health and the adverse environmental impacts associated with analytical procedures ...
Abellán Martin, Sergio J., Domini, Claudia Elizabeth, Aguirre Pastor, Miguel Ángel, Canals Hernandez, Antonio, Lorenzetti, Anabela Silvana, Acebal, Carolina Cecilia   +5 more
core   +1 more source