Results 61 to 70 of about 94,677 (268)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Subsymmetric Polynomials on Banach Spaces and Their Applications
MathematicsWe investigate algebraic and topological properties of subsymmetric polynomials on finite- and infinite-dimensional spaces. In particular, we focus on the problem of the existence of an algebraic basis in the algebra of subsymmetric polynomials, as well ...
Vitalii Bihun +3 more
doaj +1 more source
flowCore: a Bioconductor package for high throughput flow cytometry
BMC Bioinformatics, 2009 Background Recent advances in automation technologies have enabled the use of flow cytometry for high throughput screening, generating large complex data sets often in clinical trials or drug discovery settings. However, data management and data analysis
Spidlen Josef +8 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Vaught’s conjecture on analytic sets [PDF]
Journal of the American Mathematical Society, 2000 Let G G be a Polish group. We characterize when there is a Polish space X X with a continuous G G -action and an analytic set (that is, the Borel image of some Borel set in some Polish space) A ⊂ X A\subset X having uncountably many orbits but no perfect set ...
openaire +2 more sources
Capacitability for Co-Analytic Sets
New Zealand Journal of Mathematics, 2022 It follows from a theorem of Davies (1952) that if A is an analytic subset of the Cantor middle third set, λ is positive and the Hausdorff s-measure of A is greater than λ, then there is a compact subset C of A such that the Hausdorff s-measure of C is greater than λ. We exhibit a counterpoint to Davies’s theorem: In Gödel’s universe of sets, there
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
A dichotomy of sets via typical differentiability
Forum of Mathematics, Sigma, 2020 We obtain a criterion for an analytic subset of a Euclidean space to contain points of differentiability of a typical Lipschitz function: namely, that it cannot be covered by countably many sets, each of which is closed and purely unrectifiable (has a ...
Michael Dymond, Olga Maleva
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source