Results 81 to 90 of about 94,677 (268)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
A hybrid approach to evaluating digital green smart manufacturing courses
Digital EngineeringThis study proposes an integrated Interval Type-2 Fuzzy Analytic Network Process-VIseKriterijumska Optimizacija I Kompromisno Resenje for evaluating digital green mechanical engineering curricula, addressing the complexity of sustainability-focused ...
Guangdong Tian +5 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Vertex algebra constructions for (analytic) geometric Langlands in genus zero
Journal of High Energy PhysicsWe employ two-dimensional chiral algebra techniques to produce solutions of certain differential and integral equations which occur in the context of the Analytic Geometric Langlands Program. In particular, we build “Multiplication Kernels” K 3(x, x′, x′′
Davide Gaiotto
doaj +1 more source
A multilevel approach to big data analysis using analytic tools and actor network theory
South African Journal of Information Management, 2018 Background: Over the years, big data analytics has been statically carried out in a programmed way, which does not allow for translation of data sets from a subjective perspective.
Tiko Iyamu
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Measuring the metallurgical supply chain resilience using fuzzy analytic network process
Metalurgija, 2016 The article presents a methodology for measuring the metallurgical supply chain resilience, which enables the ascertainment of key resilience capabilities and measurable criteria, and determining a level of the resilience.
P. Wicher +3 more
doaj
Universal co-analytic sets [PDF]
Proceedings of the American Mathematical Society, 1996 There is a universal Π 1 1 \Pi _{1}^{1} equivalence relation. The existence of a Π 1 1 \Pi _{1}^{1} set universal for \wideutilde {\Pi }_{1}^{1} non-Borel is independent of the usual axioms of mathematics.
openaire +2 more sources