Results 181 to 190 of about 166,170,401 (203)

SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study. [PDF]

Proc Natl Acad Sci U S A
Chia PHJ, Toyonaga T, Tong J, Le H, Dias M, Boyle AJ, Raymond R, Longbrake EE, Huang Y, Carson RE, Airas L, Vasdev N, Chen MK, Zheng C.   +13 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

A Martingale-Free Introduction to Conditional Gaussian Nonlinear Systems. [PDF]

Entropy (Basel)
Andreou M, Chen N.
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

A robust and reproducible automated MRI pipeline for quantifying tissue outcomes after experimental stroke in multi-center preclinical networks. [PDF]

Imaging Neurosci (Camb)
Lynch KM, Cabeen RP, de Morais AL, Jin X, Tarakci E, Lamb J, Sanganahalli BG, Mihailovic JM, Olivas-Garcia Y, Berry DB, Diniz MA, Mandeville J, Hyder F, Thedens DR, Arbab A, Huang S, Bibic A, Austin W, Hu B, Khan MB, Kamat PK, Toga AW, Lyden P, Ayata C.   +23 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Single-Stage Causal Incentive Design via Optimal Interventions. [PDF]

Entropy (Basel)
Bejos S, Morales EF, Sucar LE, Munoz de Cote E.   +3 more
europepmc   +1 more source

Leveraging deep learning for the detection of socially desirable tendencies in personnel selection: A proof-of-concept. [PDF]

PLoS One
Lee TC, Ziegler M.
europepmc   +1 more source

Cognitive cartography of mammalian brains using meta-analysis of AI experts

Luppi AI, Ali H, Liu Z, Milisav F, Gozzi A, Bzdok D, Misic B.   +6 more
europepmc   +1 more source