Results 191 to 200 of about 421,933 (309)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Integrating Artificial intelligence within sustainable smart analytical chemistry for analyzing the divisor impact on UV-spectrophotometric efficiency of solifenacin and mirabegron combination. [PDF]

Sci Rep
Lotfy HM, Obaydo RH, Tantawy MA, Mouhamed AA.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Recent advancements in application of carbohydrate-derived carbon quantum dots in analytical chemistry: a comprehensive update. [PDF]

Bioresour Bioprocess
Berdimurodov E, Elangovan N, Kumar A, Thakur A, Sobirova F, Polvonov K, Tojieva S, Makhkamov M, Hosseini-Bandegharaei A, Sapaev I.   +9 more
europepmc   +1 more source

Nanoscale Ion-Exchange Materials: From Analytical Chemistry to Industrial and Biomedical Applications. [PDF]

Molecules, 2023
Matczuk M, Ruzik L, Keppler BK, Timerbaev AR.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Toward sustainable diagnostics for <i>Candida albicans</i>: the role of artificial intelligence in analytical chemistry from data processing to Python-based blueness and redness evaluation metrics. [PDF]

RSC Adv
Saleh AM, Hassan RYA, Badawey AM, Marzouk HM.   +3 more
europepmc   +1 more source

Analytical chemistry solutions to hazard evaluation of petroleum refining products. [PDF]

Regul Toxicol Pharmacol, 2023
Roman-Hubers AT, Cordova AC, Barrow MP, Rusyn I.   +3 more
europepmc   +1 more source

Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

Journal of Analytical Methods in Chemistry, 2021
Journal of Analytical Methods in Chemistry
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source