Results 231 to 240 of about 942,441 (368)

Proton first: rationalizing a proton transfer in a protein‐fragment complex

ChemMedChem, Accepted Article.
We present a combination of experimental and theoretical approaches to decipher the molecular recognition event of benzoic acid complexed with Protein Kinase A. The publicly known crystal structure suggests the protonated form of benzoic acid to be complexed with Protein Kinase A.
Helge Vatheuer, Jonas Paulus, Lisa Johannknecht, Gerald Keller, Rebecca Maria Ziora, Lukas Stelzl, Paul Czodrowski   +6 more
wiley   +1 more source

Sustainable Amide-Based Magnetic Dispersive Microextraction with an AQbD-Assisted Analytical Method to Detect Olanzapine from Milk-Based Food Matrices on Infusion Followed by a Green and White Assessment-Based Comparative Study. [PDF]

ACS Omega
Sundara Moorthy R, Gadthey S, Rondla R, Hu A, Reddy PM.   +4 more
europepmc   +1 more source

Potent, Selective, and Drug‐like G Protein‐coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐ray Structural Studies

ChemMedChem, Accepted Article.
We report here the design, synthesis, and evaluation of small molecules, drug‐like G protein‐coupled receptor kinase 5 (GRK5) inhibitors. GRK5 has become an important drug development target against heart failure and cancer. GRK6, a close homolog of GRK5, is considered as a possible therapeutic target for multiple myeloma.
Arun K Ghosh, Ranjith Kumar Gadi, Yueyi Chen, Sandali Piladuwa Gamage, Kathryn McCauley, John J. G. Tesmer   +5 more
wiley   +1 more source

Identification of Photochemically Generated Volatile Species of Ruthenium and Osmium Using Direct Analysis in Real Time Mass Spectrometry. [PDF]

Anal Chem
Machado I, Campanella B, Lyu Z, Musil S.
europepmc   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Green spectrofluorimetric method for quantification of sodium oxybate in pharmaceutical and plasma samples. [PDF]

Sci Rep
Alnemari RM, Almutairi FM, Aldhafeeri MM, Abduljabbar MH, Alzhrani RM, Althobaiti YS, Althobaiti MM, Ramzy S, Almalki AH.   +8 more
europepmc   +1 more source

Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone–Immune Crosstalk

ChemMedChem, EarlyView.
This article introduces quantum osteoimmunology as a novel field exploring how quantum phenomena may shape immune–skeletal signaling. This approach could help resolve longstanding questions in osteoimmune physiology and pathology. It also highlights the potential of quantum nanomaterials for ultrasensitive diagnostics and precision‐targeted ...
Rachel Wei Li, Sara Alzaanin, Zongyou Yin, Paul N. Smith   +3 more
wiley   +1 more source

Correction: Recent advances in the development of ²²⁵Ac- and ²¹¹At-labeled radioligands for radiotheranostics. [PDF]

Anal Sci
Munekane M, Fuchigami T, Ogawa K.
europepmc   +1 more source

Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent

ChemMedChem, Accepted Article.
A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama, Akira Toriba, Atsushi Shibata, Takehiko Wada, Asako Yamayoshi, Yu Mikame   +5 more
wiley   +1 more source