Results 241 to 250 of about 632,210 (313)

Integrating Multifunctionalities into a Three‐Dimensional Covalent Organic Framework for Efficient CO2 Photoreduction

open access: yesAngewandte Chemie International Edition, Accepted Article.
Fabrication of highly efficient photocatalysts for CO2 conversion is still challenging. Herein, integrating nitrogen‐rich organic cages and the photoactive porphyrin moieties together, a three‐dimensional (3D) covalent organic framework (COF), Cage‐PorCOF, is successfully synthesized.
Ke Cheng   +6 more
wiley   +1 more source

Supramolecular Recognition of a DNA Four‐Way Junction by an M2L4 Metallo‐cage, Inspired by a Simulation‐Guided Design Approach

open access: yesAngewandte Chemie International Edition, Accepted Article.
DNA four‐way junctions (4WJs) play an important biological role in DNA repair and recombination, and viral regulation, and are attractive therapeutic targets. Compounds that recognise the junction structure are rare; in this work, we describe cationic metallo‐supramolecular M2L4 cages as a new type of 4WJ binder with nanomolar affinities. A combination
Samuel J. Dettmer   +6 more
wiley   +1 more source

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis

open access: yesAngewandte Chemie International Edition, Accepted Article.
Polyether polyketides are a structurally diverse group of natural products known for their antimicrobial and antiproliferative activities. Lasalocid A is a canonical natural polyether produced by the soil bacterium Streptomyces lasalocidi. In lasalocid A biosynthesis, a polyene polyketide intermediate is converted to a bisepoxide by the flavin ...
Chu-Young Kim   +12 more
wiley   +1 more source

Annulated Radical Cations with a C4E2‐Core (E = P, As, Sb): Stable Pnictogen Analogs of Elusive Aryl Radical Anions of Birch Reduction Reactions

open access: yesAngewandte Chemie International Edition, Accepted Article.
The benzene radical anion (C6H6)●–, possessing a 7π‐electron count, is a crucial intermediate in the Birch reduction and has been extensively studied both experimentally and theoretically. Herein, we report the tricyclic pnictogen radical cations [(ADC)E]2[B], [2‐E][B] (ADC = PhC{N(Dipp)C}2; Dipp = 2,6‐iPr2C6H3; E = P, As, Sb; [B] = [B1] = B(C6F5)4 or [
Henric Steffenfauseweh   +6 more
wiley   +1 more source

Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain

open access: yesAngewandte Chemie International Edition, Accepted Article.
The helix‐hairpin‐helix (HhH) motif is an ancient and ubiquitous nucleic acid‐binding element that has emerged as a model system for studying the evolution of dsDNA‐binding domains from simple peptides that phase separate with RNA. We analyzed the entire putative evolutionary trajectory of the HhH motif – from a flexible peptide to a folded domain ...
Liam Longo   +8 more
wiley   +1 more source

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